The Wistar Institute

Centocor, Inc.

Zenon Steplewski

Hilary Koprowski

Meenhard Herlyn

Jeffrey A Mattis

David V Woo

Jan Thurin

Kenneth F Mitchell

K Ann Jeglum

Magdelena Thurin

Magdalena Thurin

The present invention is directed to in vitro and in vivo immunodiagnosis and immunotherapy using monoclonal antibodies reactive with difucosyl blood group antigens Y-6 and B-7-2.

Monoclonal antibodies against glycolipid antigens, methods of producing

The present invention is directed to monoclonal antibodies, and hybridomas which produce them, which are preferentially reactive with canine lymphoma cells and insignificantly reactive with normal canine lymphocytes.

Monoclonal antibodies against lymphoma-associated antigens, hybrid cell

A radiotherapeutic immunoconjugate comprising a tumor specific monoclonal antibody, or fragment thereof, and an Auger electron emitting radionuclide, wherein the tumor specific monoclonal antibody or fragment is capable of tumor nucleus localization of the radionuclide and method of using it is disclosed. The radiotherapeutic immunoconjugate is administered in a therapeutically effective amount to patients having or suspected of having a malignancy reactive with the antibody or fragment.

Radiotherapeutic immunoconjugates labeled with iodine-125

Monoclonal antibodies against glycolipid antigens

The present invention is directed to monoclonal antibodies, and hybridomas which produce them, which are reactive with ganglioside antigens GD2 and GD3 and are essentially non-reactive with other ganglioside antigens. The invention further relates to methods of using these antibodies.

Monoclonal antibodies against melanoma-associated antigens and hybrid

An assay for determining the Lewis blood group of a patient consists of testing a body sample for the presence of Lewis.sup.a and Lewis.sup.b antigens. Monoclonal antibodies specific for either of these antigens are employed which do not cross-react with other related antigens, such as the H blood antigen. Body samples which may be tested include: saliva, serum, urine, and paraffin-embedded tissue samples. Hybridoma cell lines and the antibody compositions they produce specific for these antigens are provided for use in the assay.

Lewis blood group phenotype assay

Colorectal carcinoma is detected by testing body fluids for the colorectal carcinoma monosialoganglioside identified by monoclonal antibodies produced by fused cell hybrid ATCC HB 8059.

Detection of colorectal carcinoma

It has been determined that 180,000 dalton molecular weight carcinoembryonic antigen has an antigen site which is not shared by other molecular weight carcinoembryonic antigens, which are released by colorectal carcinoma. A hybridoma antibody specific for the 180,000 dalton molecular weight carcinoembryonic antigen is described.

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Malvern, PA, United States of America

Zenon Steplewski