Research, Incorporated

Zenon Lysenko

Kyriacos Costa Nicolaou

William E Barnette

Ronald L Magolda

Unsaturated alcohols, thiols and thioesters are cyclized by a phenyl selenenyl halide; wherein the conformation flexibility of the unsaturated alcohol, thiol or thioester is selected such that the hydroxy group, thiol group or thioester group is capable of internal addition to at least one unsaturated bond in said alcohol, thiol or thioester; and wherein the ratio of the phenyl selenenyl halide to said unsaturated alcohol, thiol or thioester is 0.9-1.5 to 1. In a preferred embodiment, oxygen isomers and sulfur analogs of prostacyclin of the formula ##STR1## wherein X= ##STR2## Y=(E)- and (Z)- &gt;C.dbd.CH--CH.sub.2 CH.sub.2 CH.sub.2 COOR; (E)- &gt;CH--CH.dbd.CH--CH.sub.2 CH.sub.2 COOR; and

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Zenon Lysenko