Apex Neuro Holdings Inc.

3-D Matrix, Ltd.

Zen Chu

Sean Hagberg

Francois Kress

Kelsey A Fafara

Alyssa M Boasso

Miles Thibault

Julia Brock

Jainam Shah

Geoff Baldwin

Rohan Ajay Verma

Priyanka Venkatesh

Thomas R Kershaw

Christopher Wright

Lisa Spirio

Presented herein are systems, methods, and devices that provide for stimulation of nerves and/or targets such as mechanoreceptors, tissue regions, mechanoresponsive proteins, and vascular targets through generation and delivery of mechanical vibrational waves. In certain embodiments, the approaches described herein utilize a stimulation device (e.g., a wearable device) for generation and delivery of the mechanical vibrational waves. As described herein, the delivered vibrational waves can be tailored based on particular targets (e.g., nerves, mechanoreceptors, vascular targets, tissue regions) to stimulate and/or to elicited particular desired responses in a subject.

Devices and methods for delivering mechanical stimulation to nerve, mechanoreceptor, and cell targets

Transcutaneous neuromodulation device

In various aspects the present inventions provide compositions and methods for treatment of cardiac conditions. In various embodiments, the present inventions provide methods for treating a cardiac condition comprising the step of administering in a therapeutically effective amount the substantially cell free solution of an amphiphilic self-assembling peptide to a site of cardiac tissue that has been injured due to one or more of atrial fibrillation, acute myocardial infarction; valve disease, pericardial disease, congenital heart disease, congestive heart failure, and embolism.

Compositions and methods for cardiac tissue protection and regeneration

Growing community of inventors

Brookline, MA, United States of America

Zen Chu