Chinese Academy of Sciences

Ningbo Ziyuan Pharmaceuticals Inc.

Jiangsu Zuoyou Medicine Co., Ltd.

Zemin Lin

Wei Tang

Jianping Zuo

Fenghua Zhu

Shijun He

Ping Li

Chunlan Feng

Chongsheng Yuan

Yuxi Yan

Xiaoqian Yang

Provided in the present invention is a use of methyl 4-[9-(6-aminopuryl)]-2(s)-hydroxybutyrate in the preparation of a medicament for treating psoriasis and vitiligo. More specifically, the present invention uses mice whose psoriasis is induced by an imiquimod cream to observe a changing condition in skin lesions on the psoriasis-like mice, according to a psoriasis skin lesion area of the mice and grading standards for disease severity; the present invention also observes a proportion of lymphocytes in the spleens and cytokines in skin lesion tissues of the mice. A good therapeutic effect may be obtained by treating typical cases of vitiligo with an ointment of methyl 4-[9-(6-aminopuryl)]-2(s)-hydroxybutyrate. Results show that methyl 4-[9-(6-aminopuryl)]-2(s)-hydroxybutyrate used in the present invention has a good therapeutic effect on psoriasis and vitiligo, as well as a favorable prospect in clinical application.

Application of methyl 4-[9-(6-aminopuryl)]-2(s)-hydroxybutyrate in preparation of medicament for treating psoriasis and vitiligo

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Shanghai, China

Zemin Lin