Peking University

Lunan Pharmaceutical Group Corporation

Zhengzhou Granlen Pharmatech. Ltd.

Beijing Songrun Pharmaceutical Technology Co., Ltd.

Zemei Ge

Runtao Li

Xin Wang

Tieming Cheng

Jingrong Cui

Jia Ye

Liqiang Han

Qi Sun

Ding Wang

Jingchun Yao

Guimin Zhang

Haoyun An

Yingying Liang

Guifang Zhao

Yuanqiang Wang

Yongqiang Zhu

Zhuanzhuan Song

Shuyang Yao

Caiqin Yue

Changling Li

Xiaolei Du

The present application relates to a pyrazole boronic acid compound represented by the following formula I, pharmaceutically acceptable salts or stereoisomers thereof, a pharmaceutical composition containing same, and uses thereof. The compound, the pharmaceutically acceptable salts or stereoisomers thereof and the pharmaceutical composition containing same can be used for preparing proteasome inhibitors.

Pyrazole boronic acid compound, pharmaceutical composition containing same, and uses thereof

Disclosed are a compound represented by the general Formula (I), or a stereisomer, tautomer, derivative, prodrug or pharmaceutically acceptable salt thereof, and a method for preparing the compound and use of the compound in manufacture of a medicament for treating a neuropathic pain and/or neuropathic pain syndrome or a medicament for combating an inflammation:

Anti-pain compound and preparation method thereof

The present invention provides a urea peptidomimetic boronic compound and pharmaceutical compositions thereof, their preparative methods and uses. The compounds are represented by the following formula (I). 

Urea peptoid boric acid compound, pharmaceutical composition thereof, preparation method therefor, and uses thereof

The present invention discloses proteasome inhibitors of tripeptide boronic acids or boronic esters represented by Formula (I), preparative method and use thereof. The proteasome inhibitors are therapeutical agents for treating malignant tumor, various nervous system degenerative diseases, muscle cachexia or diabetes, wherein the malignant tumor is leukemia, gastric cancer, hepatocarcinoma or nasopharyngeal carcinoma. 

Tripeptide boronic acid or boronic ester, preparative method and use thereof

Compounds represented by general formula (I), their stereoisomers, tautomers, derivatives, prodrugs or pharmaceutically acceptable salts, and their preparation methods or uses for the manufacture of a medicament of analgesics. In which Ris selected from H, substituted or unsubstituted phenyl, or substituted or unsubstituted heteroaryl; A is bond, or saturated or unsaturated straight-chain or branched-chain hydrocarbon radical; R, Rare each independently hydrogen or methyl, which linked with any position of spirocyclo-structure; n and m are each independently integer between 0-2, do not represent 0 at the same time; B and D are each independently C-Cstraight-chain or branched-chain alkylene; Y is selected from &#x2014;CHR&#x2014;, O, S, &#x2014;S(O)&#x2014;, &#x2014;SO&#x2014;, &#x2014;NR&#x2014; and substituted or unsubstituted phenylene, in which Rrepresents H, C-Csaturated or unsaturated alkyl, methyl or ethyl substituted by substituted or unsubstituted aryl or heteroaryl; and Xis pharmaceutical acceptable organic or inorganic anion. These compounds can be used as muscarine receptor (M-receptor) and/or nicotine acetylcholine receptor (N-receptor) agonist or antagonist. These compounds have good analgesic effect without side effect such as addiction. 

Quaternary ammonium salt compounds of spirocyclopiperazines, preparation methods and uses thereof

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