The University of Texas System

Southwest Research Institute

Zelton Dave Sharp

Randy Strong

Paul Hasty

Carolina Livi

Arlan Richardson

Herbert Wheeler

Veronica Galvan

John R Strong

Salvatore Oddo

Herbert G Wheeler

Disclosed are methods and compositions for the treatment or prevention of intestinal polyps or prevention of cancer in a patient who has been identified as being at risk for developing intestinal polyps or intestinal cancer. The disclosed methods and compositions include rapamycin, a rapamycin analog, or another such inhibitor of the target of rapamycin (TOR).

Use of mTOR inhibitors for prevention of intestinal polyp growth and cancer

Use of mTOR inhibitors for treatment of familial adenomatous polyposis

Disclosed are microcapsules that include an inhibitor of the mammalian target of rapamycin (mTOR) within the microcapsules, and pharmaceutical compositions and kits that include the microcapsules. Also disclosed are methods for treating or preventing an age-related disease, condition, or disorder in a subject that involve administering to a subject a pharmaceutically effective amount of microcapsules that includes an inhibitor of mTOR within the microcapsules.

Inhibition of mammalian target of rapamycin

Growing community of inventors

San Antonio, TX, United States of America

Zelton Dave Sharp