Mead Johnson Nutrition Company

Mjn U.S. Holdings LLC

Zeina Jouni

Dirk Hondmann

Gyan P Rai

Francisco J Rosales

Robert J McMahon

Deborah A Schade

Kristin Morris

Eric Van Tol

Donald Carey Walker

Dattatreya Banavara

Yan Xiao

Chenzhong Kuang

Rosaline Waworuntu

Eduard K Poels

Nagendra Rangavajla

Anja Wittke

Brian Berg

Maciej Chichlowski

Deshanie Rai

Juan M Gonzalez

William Michael Russell

Win-Chin Chiang

Yung-Hsiung Lee

Hugh N Tucker

Joaquin Franco

Amar Debbouz

Zeina Makhoul

Dattatreya Banavera

Zafir Gaygadzhiev

Aedin Cassidy

Bryan Hanley

Eva Horia

Brian Kineman

Lucien Harthoorn

Kelli Talley

Taeke Kooistra

Robert Kleemann

Provided is a composition and method for modulating serotonergic receptor expression, reducing anxiety-like behavior and stress-induced inflammatory response in a pediatric subject, the method including administering to the pediatric subject a nutritional composition including lactoferrin from a non-human source and a prebiotic composition including polydextrose and/or galactooligosaccharides. Further provided is a method for reducing constipation in a pediatric subject by providing a nutritional composition including lactoferrin from a non-human source and a prebiotic composition including polydextrose and/or galactooligosaccharides.

Nutritional compositions containing a prebiotic and lactoferrin and uses thereof

A composition and method for enhancing brain development in a pediatric subject, the method including administering to the pediatric subject a nutritional composition having up to about 7 g/100 kcal of a fat or lipid source, wherein the fat or lipid source includes at least about 0.5 mg/100 kcal of milk or non-milk polar lipids; up to about 5 g/100 kcal of a protein source; at least about 15 mg/100 kcal of lactoferrin from a non-human source; about 0.015 g/100 kcal to about 0.15 g/100 kcal of a prebiotic composition including polydextrose and/or galactooligosaccharide; and at least about 5 mg/100 kcal of a source of long chain polyunsaturated fatty acids.

Nutritional compositions containing synergistic combination and uses thereof

A nutritional composition for improving the immunological function of a subject, including a lipid or fat; a protein source; about 5 to about 100 mg/100 kcal of a source of long chain polyunsaturated fatty acids which comprises docosahexanoic acid; and about 0.1 to about 1 mg/100 kcal of a prebiotic composition, wherein the prebiotic composition comprises at least 20% of an oligosaccharide which has a fermentation rate which is demonstrably slower than that of galacto-oligosaccharide.

Nutritional composition to promote healthy development and growth

Provided herein are coatings for stem cell cultureware comprising poly-L-ornithine and bovine fibronectin and methods for preparing coated stem cultureware comprising contacting cultureware with poly-L-ornithine and contacting the cultureware with bovine fibronectin. Also provided are stem cell culture media comprising epidermal growth factor, beta-fibroblast growth factor and Nsupplement.

Coatings and culture media for promoting neurogenesis in adipose tissue derived stem cells

A nutritional composition having a lipid or fat; a protein source; a source of long chain polyunsaturated fatty acids which comprises docosahexanoic acid; and up to about 2.5% by weight of a source of supplemental calcium which, when dissociated, provides a cation having prebiotic functionality.

Provided herein are methods for detecting and/or confirming the neurogenesis effect of cholesterol and/or oxysterol utilizing adipose-derived stem cells (ADSCs). Further provided are methods of promoting neurogenesis in ADSCs. Also provided are methods for the use of cholesterol and/or oxysterol for the production of a neurologic component that may be incorporated into a nutritional composition for promoting neurogenesis in a pediatric subject.

Neurogenesis screening method and uses thereof

The present disclosure is directed to methods for promoting neuronal health and/or development in a subject by providing nutritional compositions comprising a neurologic component, wherein the neurologic component may promote brain and nervous system development and further provide neurological protection and repair. The neurologic component may include lactoferrin, zinc sulfate, one or more organosulfur compounds, and mixtures thereof.

Methods for promoting neuronal development and/or health

Disclosed are methods for promoting neuronal health and/or development in a subject by providing nutritional compositions comprising docosahexaenoic acid and alpha-lipoic acid. The nutritional composition may further include lactoferrin, a prebiotic, a probiotic, and mixtures thereof. Additionally disclosed are methods for accelerating the development of neuronal activity and/or strengthening electrochemical synapse signaling by providing the nutritional composition(s) disclosed herein to a target subject.

The present invention is directed to carotenoid compositions and methods for inhibiting the growth of pathogenic bacteria or for preventing or treating bacterial infections in subjects by administration of an effective amount of astaxanthin and beta-carotene.

Carotenoid-containing compositions and methods

The present invention relates to a prenatal dietary supplement comprising at least one omega-3 fatty acid, at least one omega-6 fatty acid; folic acid; lutein; and at least one proanthocyanidin.

Prenatal dietary supplement

A novel method for determining the levels of TGF-&#x3b2;1 or TGF-&#x3b2;2 in a sample of milk, raw protein source, or nutritional composition is provided. The method involves, in some cases, reconstituting the sample; in some cases, centrifuging the sample; activating the sample using particular ratios of sample:acid:base; diluting the sample using particular ratios of sample:buffer agent; and determining the concentration of TGF-&#x3b2;1 in the sample using an ELISA assay.

Methods for determining the levels of TGF-&#x3b2; in a composition

A novel method for determining the bioactivity of TGF-&#x3b2; in a sample of milk, raw protein source, or nutritional composition is provided. The method includes particular reconstitution steps, centrifugation steps, incubation steps, and activation steps. The bioactivity of the TGF-&#x3b2; in the sample may be measured in a HT-2 cell bioassay or a cellomics bioassay.

Methods for determining the bioactivity of TGF-&#x3b2; in a composition

A nutritional formula which includes a lipid or fat; a protein source; about 5 to about 100 mg/100 kcal of a source of long chain polyunsaturated fatty acids which comprises docosahexanoic acid; about 0.1 to about 1 mg/100 kcal of a prebiotic composition, wherein the prebiotic composition comprises at least 20% of an oligosaccharide which comprises galacto-oligosaccharide; and about 0.015 to about 0.1 (pg/&#x3bc;g) ppm of TGF-&#x3b2;.

The present invention relates generally to a nutritional composition comprising punicalagins.

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Evansville, IN, United States of America

Zeina Jouni