Arsanis Biosciences Gmbh

X4 Pharmaceuticals (austria) Gmbh

Zehra Visram

Eszter Nagy

Gábor Nagy

Bianka Prinz

Irina Mirkina

Adriana Badarau

Jolanta Lukasiewicz

Luis Guachalla

Zoltán Magyarics

Astrid Teubenbacher

Manuel Zerbs

Harald Rouha

Michael Benjamin Battles

Ivana Dolezilkova

Michaela Jaegerhofer

Lukas Stulik

Bianka Dominique Prinz

The invention provides for an isolated antibody that specifically recognizes a galactan-III epitope of the lipopolysaccharide (LPS) O-antigen structure of, which epitope is incorporated in galactan-III repeating units, wherein the galactan-III repeating unit is a branched galactose homopolymer of Formula (I). The invention further provides for a pharmaceutical or diagnostic preparation comprising said antibody, and a method of producing said antibody. 

Antibodies targeting a galactan-based O-antigen of K. pneumoniae

The subject relates to a cross-neutralizing antibody comprising at least one polyspecific binding site that binds to alpha-toxin (Hla) and at least one of the bi-component toxins of, its medical and diagnostic use, method of producing the antibody, including an isolated nucleotide sequence, plasmids and host cells as used in the production of the antibody; and further an isolated conformational epitope recognized by a specific cross-neutralizing antibody.

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Vienna, Austria

Zehra Visram