Arizona State University

Arizona Board of Regents, a Body Corporate

Zehra Ilhan

Joshua LaBaer

Rosa Krajmalnik-Brown

Jin Park

Dae-Wook Kang

The present disclosure provides for characterization of normal flora and identifying biomarkers in the gut of healthy, neurotypical subjects. Aspect of the disclosure provide for the characterization of the gut microbiome in ADS subjects, characterized by reduced richness and significant loss of the '-like enterotype' compared to neurotypical subjects. The relative abundance of genera, Prevotellaceae and Veillonellaceae are significantly lower in autistic children than in neurotypical children. Further,is one of the three main classifiers for the human enterotypes, along withandThese three core genera are among main contributors in the principle component analysis. '-like enterotype' was absent in the autistic group, while neurotypical samples showed an even distribution among the three enterotypes. The present disclosure provides for an understanding the association between gut microbiota, health, and disease states, and provides for potential diagnostic and therapeutic targets.

Microbiome markers and therapies for autism spectrum disorders

The present disclosure provides for characterization of normal flora and identifying biomarkers in the gut of healthy, neruotypical subjects. Aspect of the disclosure provide for the characterization of the gut microbiome in ADS subjects, characterized by reduced richness and significant loss of the '-like enterotype' compared to neurotypical subjects. The relative abundance of genera, Prevotellaceae and Veillonellaceae are significantly lower in autistic children than in neurotypical children. Further,, is one of the three main classifiers for the human enterotypes, along withand. These three core genera are among main contributors in the principle component analysis. '-like enterotype' was absent in the autistic group, while neurotypical samples showed an even distribution among the three enterotypes. The present disclosure provides for an understanding the association between gut microbiota, health, and disease states, and provides for potential diagnostic and therapeutic targets.

Growing community of inventors

Tempe, AZ, United States of America

Zehra Ilhan