Yeda Research and Develpment & Co. Ltd

Zeev Pancer

David Wallach

Igor Mett

Mark Boldin

Eugene Varfolomeev

Tanya Goncharov

A modulator of regulatory cellular events occurring intracellularly which are mediated by regulatory proteins containing a 'death domain' motif is provided. The 'death domain' is a regulatory portion of the regulatory proteins, and the modulator is capable of interacting with one or more &#x2018;death domain&#x2019; motifs contained in the regulatory proteins and affecting the regulatory action of one or more of the regulatory proteins. The modulator preferably is capable of interacting with &#x2018;death domain&#x2019; motifs within p55-TNF-R, FAS/APO1-R, NGF-R, MORT-1, RIP, TRADD, or ankyrin. A method for producing the modulators is also provided. The modulators are useful for modulating functions mediated in cells by proteins containing the &#x2018;death domain&#x2019;.

Modulators of regulatory proteins

A modulator of regulatory cellular events occurring intracellularly which are mediated by regulatory proteins containing a &ldquo;death domain&rdquo; motif is provided. The &ldquo;death domain&rdquo; is a regulatory portion of the regulatory proteins, and the modulator is capable of interacting with one or more &ldquo;death domain&rdquo; motifs contained in the regulatory proteins and affecting the regulatory action of one or more of the regulatory proteins. The modulator preferably is capable of interating with &ldquo;death domain&rdquo; motifs within p55-TNF-R, FAS/APO1-R, NGF-R, MORT-1, RIP, TRADD, or ankryin, as illustrated in the Figure. A method for producing the modulators is also provided. The modulators are useful for modulating functions mediated in cells by proteins containing the &ldquo;death domain&rdquo;.

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Mainz, Germany

Zeev Pancer