University System of Maryland

The Uab Research Foundation

Benaroya Research Institute

Zeev Pancer

Max Dale Cooper

Chris Amemiya

G Larry Gartland

Goetz R A Ehrhardt

Li Mao

Xia Hong

Mark Z Ma

Roy A Mariuzza

Satoshi Tasumi

Carlos A Velikovsky

Goetz Ehrhardt

The invention relates to dimeric proteins comprised of subunits having (i) recombinant lamprey variable lymphocyte receptor (VLR) diversity regions linked to (ii) multimerization domains. The dimeric proteins exhibit binding specificity for glycosylated antigens, and they may be used in methods of detecting or isolating glycans from a sample, and in methods of disease diagnosis, prognosis, progression monitoring, treatment, and imaging.

Lambodies with high affinity and selectivity for glycans and uses therefor

The present invention relates to a Yeast Surface Display (YSD) vector for expression of VLR proteins by yeast, wherein the vector includes nucleotide sequences encoding segments of yeast flocculation proteins Flo1p, such as the leader and C-terminal segments, a homologous recombinant cassette and a geneticin/kanamycin resistance gene. The vector can be used for expression of VLR that may be effective in diagnostic applications (e.g., protein chip, immunohistochemistry, flow cytometry), immunoaffinity purification, and for engineering novel fusion proteins.

High affinity recombinant sea lamprey antibodies selected by a Yeast Surface Display platform

Disclosed are compositions and methods related to variable lymphocyte receptors (VLRs).

Variable lymphocyte receptors, related polypeptides and nucleic acids, and uses thereof

Variable lymphocyte receptors

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Baltimore, MD, United States of America

Zeev Pancer