Novocure Gmbh

Kla Tencor Corporation

Technion Research & Development Foundation Ltd

Zeev Bomzon

Ariel Naveh

Yoram Wasserman

Hadas Sara Hershkovich

Eilon Kirson

Noa Urman

Reuven Ruby Shamir

Moshe Giladi

Ofir Yesharim

Barak Bringoltz

Cornelia Wenger

Tali Voloshin-Sela

Gil Zigelman

Golan Bar-Tal

Oren Ben Zion Bakalo

Amnon Manassen

Yoram Palti

Mark Ghinovker

Daniel Kandel

Shira Luk-Zilberman

Pedro Michael Cavaleiro Miranda

Ori Kook

Andrew V Hill

Ohad Bachar

Erez Hasman

Mor Vardi

Vladimir Kleiner

Shay Levi

Vladimir Levinski

Eran Amit

Barry Loevsky

Guy Ben Dov

Boris Efraty

Uri Weinberg

Kristen W Carlson

Irina Vakshtein

Einav Zeevi

Tal Marciano

Yana Glozman

Ofir Aharon

Catherine Tempel-Brami

Oren Bakalo

Yissachar Avraham

Eduard G Fedorov

Oren Peles Zeevi

Hadas Hershkovich

Ariel Naeh

A method for generating a transducer layout for delivering tumor treating fields includes storing medical images of a subject, identifying one of the medical images as an anchor medical image, and registering computed tomography medical images with magnetic resonance imaging medical images. The method further includes segmenting abnormal tissue in the medical images from other tissue types and defining a region of interest (ROI) in the medical images. The method further includes creating a 3D model of the subject. The method further includes generating a plurality of transducer layouts for application of tumor treating fields to the subject, selecting at least two of the transducer layouts as recommended transducer layouts, presenting the recommended transducer layouts, receiving a user selection of at least one recommended transducer layout, and providing a report for the selected recommended transducer layout(s).

Treatment planning for tumor treating fields

The planning of treatment using tumor treating fields (TTFields) in a portion of a subject's body (e.g., the subject's head) can be improved by obtaining an image of the body portion, and generating, based on the image, a 3D model of electrical conductivity. A target volume within the 3D model is identified, and a set of model electrodes is added to the 3D model at given locations. Then, for each voxel in the target volume, the power loss density (PLD) that will be present when TTFields are eventually applied is determined. The same process is repeated for a plurality of different electrode locations. Finally, the set of electrode locations that yielded the best PLD is selected, and a description of those locations is output.

Using power loss density and related measures to quantify the dose of tumor treating fields (TTFields)

Methods, systems, and apparatuses are described for associating dielectric properties with a patient model.

Methods, systems, and apparatuses for associating dielectric properties with a patient model

Methods, systems, and apparatuses are described for managing placement of transducer arrays on a subject/patient.

Methods, systems, and apparatuses for managing transducer array placement

Methods, systems, and apparatuses are described for fast approximation of electric field distribution.

Methods, systems, and apparatuses for fast approximation of electric field distribution

A method of assisting transducer placements on a subject's body for applying tumor treating fields includes: determining, based on one or more images associated with a portion of a subject's body, a first image data, wherein the first image data comprises one or more recommended transducer placement positions; determining, based on the one or more images, a second image data, wherein the second image data comprises one or more transducer placement positions; registering the second image data to the first image data; and generating a composite data comprising the one or more transducer placement positions and the one or more recommended transducer array placement positions.

Methods, systems, and apparatuses for guiding transducer placements for tumor treating fields

Alternating electric fields (e.g., TTFields) can be delivered at a therapeutically effective strength to a target region of the spinal anatomy. In some embodiments, first and second sets of electrode elements are positioned with their centroids adjacent to upper and lower portions of the person's spine, respectively. In other embodiments, a first set of electrode elements is positioned with its centroid on an upper surface of the person's head, and a second set of electrode elements is positioned with its centroid adjacent to the person's spine (e.g., below the L3 vertebrae). Applying an AC voltage between the first and second sets of electrode elements generates a generally vertical field in the target region at levels that are not achievable using other layouts for positioning the electrode elements on the subject's body. These configurations are particularly useful for preventing and/or treating metastases.

Delivering alternating electric fields (e.g., TTFields) to a subject's spinal anatomy

Tumor treating fields (TTFields) can be delivered by implanting a plurality of sets of implantable electrode elements within a person's body. Temperature sensors positioned to measure the temperature at the electrode elements are also implanted, along with a circuit that collects temperature measurements from the temperature sensors. In some embodiments, an AC voltage generator configured to apply an AC voltage across the plurality of sets of electrode elements is also implanted within the person's body.

Delivering tumor treating fields (TTFields) using implantable transducer arrays

This application discloses configurations for arranging transducer arrays on a person's head to impose tumor treating fields (TTFields) in the brain at field strengths that are as uniform as possible throughout the entire brain. In some embodiments, L-shaped sets of electrodes are positioned near the right and left ears, each with a horizontal arm above the ear and a vertical arm behind the ear. Optionally, these embodiments may be combined with a second pair of electrodes positioned on top of the head and behind the neck. In other embodiments, one pair of electrodes is positioned above the right ear and on the left/rear portion of the neck; and a second pair of electrodes is positioned above the left ear and on the right/rear portion of the neck. These configurations improve the uniformity of the electric fields imposed throughout the brain, and are particularly useful for preventing and/or treating metastases.

Generating tumor treating fields (TTFields) with high uniformity throughout the brain

Methods, systems, and apparatuses are described for interacting with images, segmenting the images, and determining one or more regions of interest within the images.

Methods, systems, and apparatuses for image segmentation

Methods, systems, and apparatuses are described for managing temperatures induces my alternating electric fields by selectively activating/deactivating electrodes of a pair of transducer arrays according to defined parameters.

Methods, systems, and apparatuses for managing temperatures induced by alternating fields

Methods, systems, and apparatuses are described for optimizing placement of transducer arrays on a patient.

Methods, systems, and apparatuses for optimizing transducer array placement

Tumors in portions of a subject's body that have a longitudinal axis (e.g., the torso, head, and arm) can be treated with TTFields by affixing first and second sets of electrodes at respective positions that are longitudinally prior to and subsequent to a target region. An AC voltage with a frequency of 100-500 kHz is applied between these sets of electrodes. This imposes an AC electric field with field lines that run through the target region longitudinally. The field strength is at least 1 V/cm in at least a portion of the target region. In some embodiments, this approach is combined with the application of AC electric fields through the target region in a lateral direction (e.g., front to back and/or side to side) in order to apply AC electric fields with different orientations to the target region.

Arrays for longitudinal delivery of TTFields to a body

To plan tumor treating fields (TTFields) therapy, a model of a patient's head is often used to determine where to position the transducer arrays during treatment, and the accuracy of this model depends in large part on an accurate segmentation of MRI images. The quality of a segmentation can be improved by presenting the segmentation to a previously-trained machine learning system. The machine learning system generates a quality score for the segmentation. Revisions to the segmentation are accepted, and the machine learning system scores the revised segmentation. The quality scores are used to determine which segmentation provides better results, optionally by running simulations for models that correspond to each segmentation for a plurality of different transducer array layouts.

Evaluating quality of segmentation of an image into different types of tissue for planning treatment using tumor treating fields (TTFields)

Growing community of inventors

Kiryat Tivon, Israel

Zeev Bomzon