Regents of the University of Minnesota

Msp Corporation

Zeeshan Syedain

Robert T Tranquillo

Lee Meier

Robert Tranquillo

Amir A Naqwi

Christopher W Fandrey

This disclosure provides a tissue-engineered transcatheter vein valve and methods of making such a tissue-engineered transcatheter vein valve. Methods of making the valve include casting or molding a polymer into a tubular structure having a first end and a second end, where the first end of the tubular structure is cast or molded around a tubular support structure and where the second end of the tubular structure is cast or molded in the absence of the support structure; everting the polymer at the second end through the support structure; anchoring the second end of the tubular structure to the support structure at a first position and a second position, where the anchored first position and the anchored second position result in commissures, forming leaflets therebetween.

Engineered valve and method of making

This disclosure describes decellularized, biologically-engineered tubular grafts and methods of making and using such decellularized, biologically-engineered tubular grafts.

Decellularized biologically-engineered tubular grafts

A novel prosthetic valve is described herein, as well as methods of making such novel prosthetic valves.

Prosthetic valves and methods of making

A device for generating sprays of charged droplets, and resulting nanoparticles, the device comprising a first needle connected to an electrical potential line to generate a first spray of charged particles from the first needle, and a second needle spaced apart from and facing the first needle, and connected to an electrical line configured to ground the second needle or to apply a voltage to the second needle that is the same polarity as the voltage applied to the first needle. The device also comprising an electric field modifier connected to the first needle, and configured to modify an electrical field to generate a second spray of charged particles from the second needle.

Growing community of inventors

Minneapolis, MN, United States of America

Zeeshan Syedain