Universitetet | Oslo

Universitetet I Oslo

Zeeshan Muhammad

Pål Rongved

Ove Alexander Høgmoen Åstrand

Ørjan Samuelsen

Annette Bayer

Hanna-Kirsti Schrøder Leiros

Kine Susann Waade Edvardsen

Ove Alexander Høgmoen ÅStrand

Compounds according to formula I are provided:A-L-Bwherein A represents a lipophilic chelating moiety which is selective for Znions; L is a covalent bond or a linker; and B is a vector which is either a moiety capable of interacting with one or more biological structures found in a bacterium (preferably in a bacterial cell wall), for example a penicillin-binding protein such as a metallo-&#x3b2;-lactamase or DD-transferase, or a moiety capable of enhancing transport of the compound across a bacterial cell membrane. A method of treating and/or preventing a bacterial infection in a human or non-human mammal employing such compounds are also provided. In such a method, the compound of formula I may be administered in combination with (either simultaneously, separately, or sequentially) a &#x3b2;-lactam antibiotic.

Inhibitors of metallo-beta-lactamase (MBL) comprising a zinc chelating moiety

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Tromsø, Norway

Zeeshan Muhammad