Sanford Burnham Prebys Medical Discovery Institute

The United States of America, As Represented by the Secretary, Department of Health and Human Services

Technion Research & Development Foundation Ltd

The Royal Institution for the Advancement of Learning / Mcgill University

Ze'ev Ronai

Anthony B Pinkerton

Roberto Tinoco

Kevin Edward Brown

Scott Peterson

Yan Li

Shiri Ashkenazi

Linda M Bradley

Christian A Hassig

Yongmei Feng

Ivan Topisirovic

Linda Bradley

The ubiquitin ligase, RNF5, regulates the gut microbiota composition and influences the immune checkpoint response to tumors. RNF5 deficient animals exhibit significant inhibition of tumor development as well as an altered gut microbiota composition. Methods of treating cancer by administering to a subject one or more selected bacterial species and/or one or more prebiotics that promote the growth of one or more selected bacterial species are disclosed. Also disclosed are methods of treating cancer by administering to a subject one or more selected bacterial species and/or one or more prebiotics that promote the growth of one or more selected bacterial species in combination with one or more anti-cancer agents.

Gut microbiota and treatment of cancer

Provided herein are compounds and pharmaceutical compositions comprising quinolinones. The quinolinones and compositions thereof are useful as eukaryotic translation initiation factor 4F (eIF4F) complex modulators.

Quinolinones as inhibitors of translation initiation complex

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La Jolla, CA, United States of America

Ze'ev Ronai