Kimberly-clark Worldwide, Inc.

Zdravko Savov Atanassov

Rosann Marie Kaylor

Michael E Knotts

Kaiyuan Yang

Ning Wei

Difei Yang

Chibueze Obinna Chidebelu-Eze

Xuedong Song

David S Cohen

Shawn Ray Feaster

Michael Eugene Knotts

Hollow particles for use in various types of assay devices are provided. Due to their hollow or voided structure, the particles may exhibit a variety of beneficial properties. For instance, hollow particles are generally lightweight, and thus, relatively inexpensive in comparison to other types of particles. Hollow particles may also form a stable system without requiring refrigeration or rotation. In addition, hollow particles may possess enhanced light diffraction capabilities, which may be particularly beneficial in certain types of assay devices, e.g., diffraction-based assay devices.

Methods of making assay devices utilizing hollow particles

Assay devices that utilize hollow particles

A system that employs transmission-based detection techniques to determine the presence or concentration of an analyte within a test sample is provided. Specifically, the optical detection system contains a chromatographic-based assay device that is positioned in the electromagnetic radiation path defined between an illumination source and detector. To enhance the sensitivity and signal-to-noise ratio of the system without significantly increasing costs, the distance between the illumination source and/or detector and the assay device is minimized. The illumination source and/or detector may also be positioned directly adjacent to the assay device. In addition, the system may be selectively controlled to reduce reliance on external optical components, such as optical filters or diffusers.

Optical detection system using electromagnetic radiation to detect presence or quantity of analyte

An analyzer useful in determining the presence of an analyte using a diffraction based sensing device and methods and systems using this device. The present invention may be used with a variety of different diffraction-based diagnostic methods and systems. The analyzer enhances the accuracy and/or usefulness of these devices in detecting analytes, while providing more ease-of-use and convenience to the user. The analyzer may include a light source, a photodiode, a microprocessor and a display system for informing the user of the result. Other features include mirrors, lenses, a sample holder, and a mask for blocking out some light. The analyzer and related method and system may be used in a large number of environments, including commercial, professional, and individual.

Systems to view and analyze the results from diffraction-based diagnostics

Methods to view and analyze the results from diffraction-based diagnostics

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Alpharetta, GA, United States of America

Zdravko Savov Atanassov