Pliva Hrvatska D.o.o.

Jadran - Galenski Laboratorij D.d.

Zdravka Knezevic

Gorjana Lazarevski

Aleksandar Danilovski

Darko Filic

Miljenko Dumic

Mladen Vinkovic

Dominik Cincic

Alojz Dumbovic

Katica Lazaric

Marina Oresic

Ernest Mestrovic

Dejan Kresimir Bucar

Nina Popovic

Vesna Sarson

Karina Vukelic

Silvija Kamber

Marina Mavrinac

Laura Simic

Substantially pure isostructural pseudopolymorphs of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin A having the Formula I: wherein S is an organic solvent which is at least partially miscible with water, x is 1, 1.25, 1.5 or 2, y is 0, 0.5, or 1, the pseudopolymorph being characterized by the monoclinic space group P2and average unit cell parameters comprising: crystal axis lengths of a=15.5-17.0 &#x212b;, b=15.5-17.0 &#x212b;, and c=17.5-19.5 &#x212b;, and angles between the crystal axes of &#x3b1;=&#x3b3;=90&#xb0; and &#x3b2;=106&#xb0;-112&#xb0;. In addition, this disclosure is directed to processes for the preparation of the substantially pure isostructural pseudopolymorphs of Formula I; to pharmaceutical compositions containing substantially pure isostructural pseudopolymorphs of Formula I; and to a method for the treatment of bacterial and protozoan infections, and inflammation-related diseases by administration of a pharmaceutical composition containing the substantially pure isostructural pseudopolymorphs of Formula I.

Isostructural pseudopolymorphs of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin A

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Zagreb, Croatia

Zdravka Knezevic