Fotona D.o.o.

Fotona D.d.

Zdenko Vizintin

Matjaz Lukac

Marko Kazic

Tadej Perhavec

Franci Bajd

Boris Cencic

Marcelo Tettamanti

A treatment method for non-ablative tissue regeneration includes directing at least one laser pulse having a wavelength onto a tissue surface of a human or animal body, and controlling an energy delivery time tof the at least one laser pulse, during which the second half of the pulse energy is delivered, to be sufficiently short, so that, given the wavelength and thus a corresponding penetration depth δ of the at least one laser pulse, a thermal exposure time tof the tissue surface is smaller than 900 microseconds. The thermal exposure time tof the tissue surface is defined as a time interval in which the temperature of the tissue surface is above T+(T−T)/, wherein Tdefines the initial temperature of the tissue surface, before the laser pulse arrives, and Tis a maximal temperature of the tissue surface.

Apparatus and method for tissue regeneration

A treatment method for non-ablative tissue regeneration includes directing at least one laser pulse having a wavelength onto a tissue surface of a human or animal body, and controlling an energy delivery time tof the at least one laser pulse, during which the second half of the pulse energy is delivered, to be sufficiently short, so that, given the wavelength and thus a corresponding penetration depth &#x3b4; of the at least one laser pulse, a thermal exposure time tof the tissue surface is smaller than 900 microseconds. The thermal exposure time tof the tissue surface is defined as a time interval in which the temperature of the tissue surface is above T+(T&#x2212;T)/2, wherein Tdefines the initial temperature of the tissue surface, before the laser pulse arrives, and Tis a maximal temperature of the tissue surface.

An apparatus for tissue regeneration is provided. The apparatus comprises means for generating at least one laser pulse comprising a wavelength; and means for directing the at least one laser pulse onto a tissue surface of a human or animal body, wherein the means for generating comprises control means to ensure that a sum of the pulse energies of the at least one laser pulse is selected so that the corresponding fluence on the tissue surface heats the tissue surface up to a maximal temperature Tbetween 70&#xb0; C. and a tissue boiling temperature T. Further, the means for generating of the apparatus are adapted so that a delivery time tof the at least one laser pulse (during which the second half of the pulse energy is delivered) is sufficiently short so that, given the wavelength and thus a corresponding penetration depth &#x3b4; of the at least one laser pulse, a thermal exposure time tof the tissue surface is shorter than 900 microseconds. Here, the thermal exposure time tof the tissue surface is defined as a time interval in which the temperature of the tissue surface is above T+(T&#x2212;T)/2, wherein Tdefines the initial temperature of the tissue surface, before the laser pulse arrives.

For lightening or eradicating pigments in human skin, a first conditioning laser optical energy having first optical parameters selected to obtain an ablative effect on the epidermal layer of human skin is provided. A target area of the human skin is conditioned by directing the first conditioning laser optical energy onto the target area and forming in an epidermal layer of the target area discrete pressure and gas release ducts across the target area. A second treatment laser optical energy is provided that has second optical parameters selected to obtain a lightening or eradicating effect on the pigments located within the human skin and to substantially avoid damaging the epidermal layer of the human skin. The second treatment laser optical energy is directed onto the target area subsequent to conditioning, and the pigments within the human skin are lightenmed or eradicated by the second treatment laser optical energy.

Method for lightening or eradicating pigments in human skin

A laser system has a laser source for generating a laser beam, a control unit, and a hand piece for manually guiding the laser beam onto a target area. A wavelength (&#x3bb;) of the laser beam is in a range from above 1.9 &#x3bc;m to 11.0 &#x3bc;m inclusive. The laser system is adapted for a thermal, non ablative treatment of mucosa tissue by the laser beam such, that the laser source generates the laser beam in single pulses with a pulse duration (t) in a range from 1.0 &#x3bc;s, inclusive, to 1.0 sec, inclusive, and that a fluence of each of the single pulses on the target area of the mucosa tissue is in a range from 0.2 J/cm, inclusive, to 2.5 J/cm, inclusive, and preferably in a range from 1.40 J/cm, inclusive, to 1.95 J/cm, inclusive.

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Ljubljana, Slovenia

Zdenko Vizintin