Ustav Organicke Chemie a Biochemie Av Cr, V.v.i.

Ustav Organicke Chemie a Biochemie Akademie Ved Cr, V.v.i.

Ustav Experimentalni Mediciny Akademie Ved Cr, V.v.i.

Ustav Experimentalni Mediciny Av Cr, V.v.i.

Zdenek Zidek

Zlatko Janeba

Antonin Holy

Viktor Kolman

Filip Kalcic

Petr Jansa

Eva Kmonickova

The invention describes the pyrimidine-based compounds of the general formula I. Described compounds lower the production of the prostaglandin E. In concentrations lowering production of this factor by 50%, these compounds have no negative effect on the cell viability and they are not cytotoxic. Furthermore, the method of production of the compounds of the general formula I is provided. A pharmaceutical composition comprising the polysubstituted pyrimidines according to the invention and the use of these compounds for the treatment of the inflammatory diseases are also provided.

Polysubstituted pyrimidines inhibiting the formation of prostaglandin E2, a method of production thereof and use thereof

The invention provides pyrimidine compounds of general formula (I), which reduce simultaneously the production of nitric oxide (NO) and prostaglandin E2 (PGE2). They have no negative effect on the viability of cells in concentrations decreasing the production of these factors by up to 50%; they are not cytotoxic. Furthermore, a method of preparation of the pyrimidine compounds of general formula (I), carrying 2-formamido group, a pharmaceutical composition comprising the substituted pyrimidine compounds according to the invention, and the use of these compounds for the treatment of inflammatory and cancer diseases are provided. 

Pyrimidine compounds inhibiting the formation of nitric oxide and prostaglandin E2, method of production thereof and use thereof

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Zdenek Zidek