The Ohio State University

Zbigniew Walaszek

Thomas E Webb

Dorothy E Schumm

John P Minton

Margaret Hanausek-Walaszek

Raymond W Lang

Malgorzata Hanausek-Walaszek

Materials can be screened for carcinogenic properties by administering them to test animals and assaying biological tissue, preferably plasma, for the presence of a 60K cancer-associated phosphoprotein. The test is applicable to a wide range of chemically-diverse carcinogens and is not restricted to carcinogens having one particular mode of action.

Process for testing the carcinogenicity of a material or the presence of

A method for the reduction in vivo of the inappropriate levels of endogenous and environmental-derived compounds by inhibiting the activity of .beta.-glucuronidase in a mammal which comprises the administration to the mammal of an effective amount of a water insoluble, or sparingly soluble, sustained release precursor of glucarolactone or its analog is disclosed. The sustained release precursor of glucarolactone compound is selected from the group consisting of D-glucaric acid, D-galactaric acid, and L-idaric acid or derivatives or analogs. An orally administrable preparation of the sustained release precursor of glucarolactone compound is provided in the form of a capsule tablet, such that the glucarolactone or its analog is slowly released in the stomach of the treated animal or human.

Reduction in vivo of the inappropriate levels of endogenous and

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Columbus, OH, United States of America

Zbigniew Walaszek