Vdf Futureceuticals, Inc.

Icn Pharmaceuticals, Inc.

Other

Valeant Research and Development

Proxy Life Sciene Holdings, Inc.

Proxy Life Science Holdings, Inc.

Topgene, Inc.

Zbigniew Pietrzkowski

Dusan Miljkovic

Dariusz Cieslak

Esmir Gunic

Wayne Carl Thresher

Jovan Hranisavljevic

Gordana Olbina

Guangyi Wang

Zhi Hong

Jean-Luc Girardet

Johnson Lau

Wilfried E Seifert

Sabera Ruzdijic

Compositions and methods are presented that substantially increase levels of BDNF in blood, and even more pronouncedly exosomal BDNF levels. Suitable compositions include whole coffee fruit extracts and powders that are orally administered at relatively low dosages.

Compositions and methods of BDNF activation

Compositions, methods, and uses are contemplated in which a betalain-containing preparation is administered to a mammal to enhance athletic performance. Most preferably, the preparations are substantially nitrate free and acutely and transiently increase hematocrit, erythropoietin, adrenalin, and beta endorphin, while reducing serum lactate, serum lactate dehydrogenase, heart rate and a rate of perceived exertion.

Compositions and methods for increasing athletic performance

Contemplated compositions and methods employ betalains for treatment of various conditions, and especially osteoarthritis, sinusitis, contact dermatitis, acne, an allergic condition, reduced mental alertness, reduced physical strength, reduced physical endurance, and/or impaired mood.

Betalain compositions and methods therefor

Solid, free-flowing, and substantially completely dissolvable preparations with high betalain content are presented. Most typically, the betalain profile of the preparations is near natural and includes betalains in an amount of between 10-40 wt %. As the preparations of the inventive subject matter maintain chemical stability and flowability over extended periods of time, it should be noted that the betalain preparations are now amenable to compounding in small and measured quantities. Furthermore, new biological activities of betalains are shown, and especially include significant induction of SIRT and reduction of serum triglyceride.

Solid betalain compositions and methods

Compositions and methods for dietary supplements that contain a cold-water extract of humic shale and/or an extract of the apple fruit or skin of the apple fruit that is/are effective to modulate in vivo cytokines, oxygen consumption rate, extracellular acidification rate, and ATP production.

Compositions and methods for improved energy metabolism

Contemplated compositions and methods are drawn to use of various boron-containing compounds to temporarily and transiently increase endogenous blood calcitriol concentration. The boron-containing compound is preferably a carbohydrate-boron complex having sufficient stability to achieve measurable quantities of the complex in blood upon oral administration of the complex.

Compositions and methods related to calcitriol

Betalain compositions and uses thereof

Complex metal-containing matrices, and especially chromium-containing matrices are produced from a water soluble preparation that is derived from an item suitable for animal (and most typically human) consumption. In particularly contemplated aspects, the water soluble preparation is an extract or filtrate of disintegrated brewer's yeast, and the so prepared complex mixture is combined with a chromium-3ions.

Methods and compositions for improved chromium complexes

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Aliso Viejo, CA, United States of America

Zbigniew Pietrzkowski