Duke University

Immunolight, LLC

Immunoloight, Llc.

Zak Fathi

Frederic Avery Bourke, Jr

Michael J Therien

Ian Nicholas Stanton

Tuan Vo-Dinh

Joseph H Simmons

Jennifer Ann Ayres

Joshua T Stecher

Benoit Lauly

Molly K Gregas

Zhenyuan Zhang

Jonathan P Scaffidi

Yan Zhang

Venkata Gopal Reddy Chada

Harold Walder

Diane Renee Fels

Paolo Maccarini

Stephen John Norton

Cory Robert Wyatt

Mark Wesley Dewhirst

Paul Rath Stauffer

Frederic A Bourke

Jennifer Ayres

Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by placing a nanoparticle having a metallic shell on at least a fraction of a surface in a vicinity of a target structure in a subject and applying an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The nanoparticle is configured, upon exposure to a first wavelength &#x3bb;, to generate a second wavelength &#x3bb;of radiation having a higher energy than the first wavelength &#x3bb;. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.

Non-invasive energy upconversion methods and systems for in-situ photobiomodulation

Non-invasive energy upconversion methods and systems

A system and a conversion element for power conversion. The power conversion system includes a power conversion device which produces electric power upon illumination and includes a light conversion device which down-converts and up-converts a radiant source of energy into a specific energy spectrum for the illumination of the power conversion device. The conversion element includes a first plurality of particles which upon radiation from a first radiation source radiate at a higher energy than the first radiation source, and includes a second plurality of particles which upon radiation from the first radiation source radiate at a lower energy than the first radiation source. At least one of the first plurality of particles and the second plurality of particles can be at least partially metal coated.

Up and down conversion systems for improved solar cell performance or other energy conversion

System for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The system can be used in methods which can be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure.

A nanoparticle-based system for enhancement of emitted light inside a medium. The nanoparticle-based system includes a phosphorescent material which, upon activation, produces the emitted light, and a metallic structure attached to the phosphorescent material. The metallic structure has a surface plasmon resonance which resonates at a frequency which spectrally overlaps with one or more frequencies of the emitted light.

Products, compositions, systems, and methods for modifying a target structure. The methods may be performed in a non-invasive manner by placing a nanoparticle having a metallic shell on at least a fraction of a surface in a vicinity of a target structure in a subject and applying an initiation energy thus producing an effect on or change to the target structure directly or via a modulation agent. The nanoparticle is configured, upon exposure to a first wavelength &#x3bb;, to generate a second wavelength &#x3bb;of radiation having a higher energy than the first wavelength &#x3bb;. The methods may further be performed by application of an initiation energy to activate a photoactivatable agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure.

A system for energy upconversion and/or down conversion and a system for producing a photostimulated reaction in a medium. These systems include 1) a nanoparticle configured, upon exposure to a first wavelength &#x3bb;of radiation, to generate a second wavelength &#x3bb;of radiation having a higher energy than the first wavelength &#x3bb;and 2) a metallic structure disposed in relation to the nanoparticle. A physical characteristic of the metallic structure is set to a value where a surface plasmon resonance in the metallic structure resonates at a frequency which provides a spectral overlap with either the first wavelength &#x3bb;or the second wavelength &#x3bb;, or with both &#x3bb;and &#x3bb;. The system for producing a photostimulated reaction in a medium includes a receptor disposed in the medium in proximity to the nanoparticle which, upon activation by the second wavelength &#x3bb;, generates the photostimulated reaction.

Up and down conversion systems for production of emitted light from various energy sources

Growing community of inventors

Raleigh, NC, United States of America

Zak Fathi