Mount Sinai School of Medicine

Icahn School of Medicine at Mount Sinai

Other

General Electric Company

Koninklijke Philips Corporation N.v.

Massachusetts Institute of Technology

Siemens Medical Solutions Usa, Inc.

The Brigham and Women's Hospital, Inc.

Ge Medical Systems Global Technology Company, LLC

The Mount Sinai Medical Center

Magna-lab Inc.

Memorial Sloan Kettering Cancer Center

Zahi A Fayad

Edward A Fisher

Venkatesh Mani

Thomas K F Foo

Lawrence A Minkoff

Francois Fay

Valentin Fuster

Meir Shinnar

Vitalii Itskovich

Juan J Badimon

Robert Samuel Langer

Omid C Farokhzad

Jason S Lewis

Melanie Suzanne Kotys

Gwendalyn J Randolph

Stefan E Fischer

John T Fallon

Michael M Szimtenings

Jonathan Feig

Willem Mulder

Jordi Ochando

Raphaël Duivenvoorden

Mounia Braza

Chara Itskovich, Legal Representative

Daniel D Samber

Eugene Trogan

Kevin J Williams

Sarayu Ramachandran

Philip Martyn Robson

Claudia Calcagno-Mani

Willem J Mulder

YongTae Kim

Carlos Perez-medina

Willem JM Mulder

Edward Fisher

Methods and compositions for inducing long-term tolerance by hybrid nanoparticles are provided. Compositions and formulations comprising hybrid nanoparticles with inherent affinity for innate immune cells are provided.

Targeting the innate immune system to induce long-term tolerance and to resolve macrophage accumulation in atherosclerosis

Methods for making particles, such as nanoparticles, devices useful in the methods, and particles made by the method are described herein. The methods involves the use of microfluidic device, such that upon mixing solutions of the materials to form the particles (or a solution of the material or materials to form the particles and a non-solvent for the material or materials) at least two symmetrical microvortices are formed simultaneously. The method can be used to prepare polymeric or non-polymeric particles and hybrid particles, such as lipid-polymer hybrid particles, as well as such particles containing one or more agents associated with the particles.

Mass production and size control of nanoparticles through controlled microvortices

A dual magnetic resonance imaging method simultaneously acquires a first and a second time series of MR images wherein the temporal resolution of the first time series of images is larger than that of the second time series while the spatial resolution of the first time series of images is smaller than that of the second time series. Accordingly, in the context of DCE-MRI, the first time series can be used to determine the arterial input function (AIF) while the second time series can be used to determine the concentration time course in the tissue of interest, e.g. in a vessel wall. Therefore, both the AIF and the tissue time course can be acquired with their optimal dynamic signal range.

Simultaneous high spatial low temporal resolution magnetic resonance (MR) sequence for dynamic contrast enhanced (DCE) magnetic resonance imaging (MRI)

The present invention is directed to synthetic nanoparticles useful as imaging agents for use in MRI, CT, Gamma-scintigraphy, or optical imaging techniques. The synthetic nanoparticles comprise at least one apolipoprotein that is not an apoB lipoprotein, at least one amphipathic lipid, and at least one metallic or non-metallic contrast agent linked through a chelator to a component of the nanoparticle, wherein the one metallic or non-metallic contrast agent is present in an amount of between 5% to about 50% (w/w) of the nanoparticle, and the nanoparticle has a diameter of from about 5 nm to about 50 nm. Compositions and kits comprising the synthetic nanoparticles and methods of making and using the same are also provided.

Methods and compositions for imaging

The present invention is directed to compositions useful as imaging agents for use in monitoring atherosclerotic plaque regression using, for example, MRI, CT, Gamma-scintigraphy, or optical imaging techniques. Methods and compositions of using the same are described.

A multicontrast-weighted acquisition of three images is performed with an MRI system. Each image is normalized and then mapped to a separate color channel. A composite color image is formed by combining all the color channels, and this image is displayed or analyzed to identify different tissue types therein.

Display and analysis of multicontrast-weighted magnetic resonance images

The invention includes a technique for efficient multi-slice fast spin echo image acquisition with black blood contrast in cardiac imaging. The technique includes applying a non-selective inversion pulse, followed by a re-inversion pulse that is slice-selective over a region encompassing a plurality of slice selections. Execution of a series of RF excitation pulses with fast spin echo readout is timed such that signal from blood is near a null point before acquiring data for each spatial slice. For greater contrast consistency, the flip angles for the excitation pulses occurring before the null point can be reduced, and those occurring after the null point can be increased.

Efficient multi-slice acquisition with black blood contrast in fast spin echo imaging

DIR imaging of blood vessels by administering a series of DIR preparation pulse modules at a repetition interval short enough that at least two DIR preparation pulse modules generally occur within each RR interval, and by acquiring image data for a plurality of slices following each DIR module.

Rapid multislice black blood double-inversion recovery technique for blood vessel imaging

The magnetic resonance catheter antenna includes a first tube having a proximal end and a distal end. A litz wire has a first end and a second end and is looped within the first tube such that the first end and the second end are disposed at the proximal end. A guide wire is disposed within the first tube. A multifilament or solid wire may be used instead of a litz wire. At least the looped portion of the wire is insulated.

Catheter antenna for magnetic resonance imaging

Efficient multi-slice acquisition with black blood contrast

A magnetic resonance image receiving coil includes a first balloon having a longitudinal axis. An internal surface of the first balloon defines an internal inflatable chamber. A second balloon has a longitudinal axis. The second balloon is disposed about the first balloon. A plurality of longitudinally extending grooves are disposed in one of an external surface of the first balloon and the internal surface of the second balloon. A first wire is disposed in at least one of the grooves. A second wire is disposed in at least a second one of the grooves. Each of the first wire and the second wire is adapted to be electrically connected to an MRI apparatus. In accordance with an alternate embodiment, the first and second wires are disposed in grooves in a sheath which is disposed between the first and second balloons. In accordance with a further alternate embodiment, the first and second wires are disposed in guide tubes that are connected to the external surface of a balloon.

Expandable MRI receiving coil

Growing community of inventors

New York, NY, United States of America

Zahi A Fayad