Proveris Scientific Corporation

Gene Network Sciences, Inc.

Zachary W Pitluk

Dino J Farina

Iya G Khalil

Colin C Hill

Bruce W Church

Thomas A Neyarapally

Paul D McDonagh

The methods described herein provide improvements to the measurement of dose content uniformity of inhaler and nasal devices. The methods involve analyzing and measuring a spray pattern of an emitted spray from an inhaler or nasal device. The spray pattern may be used to determine the dose content uniformity of an inhaler or nasal device.

Methods for measuring dose content uniformity performance of inhaler and nasal devices

The systems and methods described herein utilize a probabilistic modeling framework for reverse engineering an ensemble of causal models, from data and then forward simulating the ensemble of models to analyze and predict the behavior of the network. In certain embodiments, the systems and methods described herein include data-driven techniques for developing causal models for biological networks. Causal network models include computational representations of the causal relationships between independent variables such as a compound of interest and dependent variables such as measured DNA alterations, changes in mRNA, protein, and metabolites to phenotypic readouts of efficacy and toxicity.

Systems and methods for modeling and analyzing networks

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New Haven, CT, United States of America

Zachary W Pitluk