Reata Pharmaceuticals, Inc.

Zachary S Sheldon

Xin Jiang

Melean Visnick

Bradley W Caprathe

Gary Louis Bolton

Chitase Lee

Christopher F Bender

Martha R Hotema

Brian Edward Kornberg

Brian Kornberg

Bradley William Caprathe

Disclosed herein are compounds of the formulas: as well as analogs thereof, wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used to inhibit RORγ and/or reduce the expression of IL-17. Also provided are methods of administering compounds and composition provided herein to a patient in need thereof, for example, for the treatment or prevention of diseases or disorders associated with inflammation or autoimmune disorders.

Pyrimidine tricyclic enone derivatives for inhibition of ROR-gamma and other uses

Disclosed herein are compounds of the formulas: as well as analogs thereof, wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used to inhibit ROR&#x3b3; and/or reduce the expression of IL-17. Also provided are methods of administering compounds and composition provided herein to a patient in need thereof, for example, for the treatment or prevention of diseases or disorders associated with inflammation or autoimmune disorders. 

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Dallas, TX, United States of America

Zachary S Sheldon