Array Biopharma Inc.

Ventirx Pharmaceuticals, Inc.

Zachary Jones

Joseph P Lyssikatos

George A Doherty

Robert D Groneberg

C Todd Eary

Laurence Edward Burgess

Robert Hershberg

Gregory Dietsch

James Jeffry Howbert

Charles Todd Eary

Hong Woon Yang

Todd C Eary

Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, infectious disease, inflammatory disorder, graft rejection, and graft-verses-host disease.

Substituted benzoazepines as toll-like receptor modulators

Provided are compositions and methods useful for modulation signaling through the Toll-like receptor TLR8. The compositions and methods have use in the treatment of autoimmunity, inflammation allergy, asthma, graft rejection, graft versus host disease, infection, sepsis, cancer and immunodeficiency.

Aminodiazepines as toll-like receptor modulators

Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in the treatment of autoimmunity, inflammation allergy, asthma, graft rejection, graft versus host disease, infection, sepsis, cancer and immunodeficiency.

8-substituted benzoazepines as toll-like receptor modulators

Growing community of inventors

Broomfield, CO, United States of America

Zachary Jones