St. Jude Medical Puerto Rico LLC

Tendyne Holdings, Inc.

J.d. Franco & Co., LLC

St. Jude Medical, Inc.

Terumo Puerto Rico, L.l.c.

Boston Scientific Scimed, Inc.

Zachary J Tegels

Robert M Vidlund

Mark R Christianson

Thomas J Holman

Yousef F Alkhatib

Daniel James Horn

Craig A Ekvall

Russell David Terwey

Edward E Parsonage

Michael Calhoun

Troy White

Michael Eugene Evans

Richard Charles Gunderson

Martha Escobar

Stephen Michael

Chad Perrin

Bernhard Kaeferlein

Timothy M McGlinch

Steven Nicholas Willard

Michael J Urick

Son Mai

John Fritz Otte

Igor Kovalsky

Catherine A Pipenhagen

Douglas P Killion

Jason M Halac

Andrzej M Malewicz

Richard L Goodin

Adam Jennings

Katherine M Prindle

Richard A Noddin

Ying Xiong

Zachary Vidlund

Doreen Borgmann

Khoi Le

Ali Hassan

Khoi A Le

Mary Bronson

Tom Holman

Richard Dunn

The Thomas Trinh Tran

John Ibeling

Gerald W Grabowski

James A McCrea

Karen Turner

Zihan Lin

Ben Arcand

Dan Quillin

Zach Vidlund

Steve Hoff

Kathy Prindle

Mark Sagedahl

Philip J Ebeling

Robert Lucas

Troy T White

Michael Evans

John W Ibeling

A method may include accessing an artery in communication with an ophthalmic artery of a subject, and advancing a microcatheter along the accessed artery so as to align a distal end of the microcatheter with an ostium of the ophthalmic artery, wherein the microcatheter includes a lumen having a guidewire positioned therein. In addition, the method includes proximally withdrawing the guidewire relative to the microcatheter so as to enable a distal portion of the microcatheter to assume a curved relaxed configuration, and cannulating the ostium with the distal portion of the microcatheter when the distal portion is in the curved relaxed configuration.

Intravascular devices, systems, and methods to address eye disorders

Apparatus and methods are described herein for various embodiments of a prosthetic heart valve, delivery apparatus and delivery methods for delivering a prosthetic heart valve to a heart of a patient via a transapical or transvascular delivery approach. In some embodiments, a prosthetic heart valve includes an outer frame coupled to an inner frame and the outer frame is movable between a first configuration relative to the inner frame and a second inverted configuration relative to the inner frame. The valve can be delivered to a heart using an apparatus that includes a delivery sheath that defines a lumen that can receive the prosthetic heart valve therein when the outer frame is in the inverted configuration. Actuation wires are releasably coupled to the outer frame and can be used to help revert the outer frame after the valve is deployed outside of the delivery sheath and within the heart.

Prosthetic heart valves and apparatus and methods for delivery of same

A self-expanding wire frame for a pre-configured compressible transcatheter prosthetic cardiovascular valve, a combined inner frame/outer frame support structure for a prosthetic valve, and methods for deploying such a valve for treatment of a patient in need thereof, are disclosed.

Structural members for prosthetic mitral valves

Apparatus and methods are described herein for a secondary valve apparatus that can be deployed within an existing implanted prosthetic heart valve. In some embodiments, a secondary prosthetic heart valve apparatus is implanted in series with an existing deteriorating implanted prosthetic valve. The secondary valve apparatus can restore proper valve function without disruption to the failing previously implanted valve. In some embodiments, the secondary valve apparatus can be positioned on an atrial portion of the existing valve, and be delivered transseptally. In other embodiments, the secondary valve apparatus can be positioned at a ventricular portion of the existing valve and delivered transapically. Devices and methods to prepare the existing valve to receive a secondary valve apparatus are also described herein. In some embodiments, a balloon expansion device can be used to expand an inner diameter of the existing valve to provide space for the secondary valve to be disposed.

Apparatus and methods for delivery of a prosthetic valve within an existing implanted prosthetic valve

Apparatus and methods are described herein for use in the delivery and deployment of a prosthetic mitral valve into a heart. In some embodiments, an apparatus includes a catheter assembly, a valve holding tube and a handle assembly. The valve holding tube is releasably couplable to a proximal end portion of the catheter assembly and to a distal end portion of the handle assembly. The handle assembly includes a housing and a delivery rod. The delivery rod is configured to be actuated to move distally relative to the housing to move a prosthetic heart valve disposed within the valve holding tube out of the valve holding tube and distally within a lumen of the elongate sheath of the catheter assembly. The catheter assembly is configured to be actuated to move proximally relative to the housing such that the prosthetic valve is disposed outside of the lumen of the elongate sheath.

Apparatus and methods for delivery, repositioning, and retrieval of transcatheter prosthetic valves

A prosthetic heart valve can include an outer support assembly, an inner valve assembly, which define between them an annular space, and a pocket closure that bounds the annular space to form a pocket in which thrombus can be formed and retained. Alternatively, or additionally, the outer support assembly and the inner valve assembly can be coupled at the ventricle ends of the outer support assembly and the inner valve assembly, with the outer support assembly being relatively more compliant in hoop compression in a central, annulus portion than at the ventricle end, so that the prosthetic valve can seat securely in the annulus while imposing minimal loads on the inner valve assembly that could degrade the performance of the valve leaflets.

Thrombus management and structural compliance features for prosthetic heart valves

Apparatus and methods are described herein for use in the delivery of a prosthetic mitral valve. In some embodiments, an apparatus includes an epicardial pad configured to engage an outside surface of a heart to secure a prosthetic heart valve in position within the heart. The epicardial pad defines a lumen configured to receive therethrough a tether extending from the prosthetic valve. The epicardial pad is movable between a first configuration in which the epicardial pad has a first outer perimeter and is configured to be disposed within a lumen of a delivery sheath and a second configuration in which the epicardial pad has a second outer perimeter greater than the first outer perimeter. The epicardial pad can be disposed against the outside surface of the heart when in the second configuration to secure the prosthetic valve and tether in a desired position within the heart.

Expandable epicardial pads and devices and methods for delivery of same

This invention relates to the design and function of a retrieval device for a prosthetic heart valve for re-positioning or removal of a previously implanted valve prosthesis from a beating heart without extracorporeal circulation using a transcatheter retrieval system.

Retrieval and repositioning system for prosthetic heart valve

A prosthetic heart valve includes a self-expanding wire frame body, a valve disposed in the body, a leaflet clip coupled to the body, and a control element operably coupled to the leaflet clip. The body has a proximal end and a distal end. The leaflet clip is configured to be transitioned between a first configuration in which the prosthetic valve can be inserted into a heart, and a second configuration in which the leaflet clip is disposed to capture a native valve leaflet between the leaflet clip and the wire frame body when the body is disposed in a native annulus of an atrioventricular valve of a heart. The control element extends from the leaflet clip through a ventricle of the heart and out a wall of the ventricle to allow a user to transition the leaflet clip from its first configuration to its second configuration.

Prosthetic heart valve and systems and methods for delivering the same

In some embodiments, a method includes delivering to a native valve annulus (e.g., a native mitral valve annulus) of a heart a prosthetic heart valve having a body expandable from a collapsed, delivery configuration to an expanded, deployed configuration. The method can further include, after the delivering, causing the prosthetic heart valve to move from the delivery configuration to the deployed configuration. With the prosthetic heart valve in its deployed configuration, an anchor can be delivered and secured to at least one of a fibrous trigone of the heart or an anterior native leaflet of the native valve. With the prosthetic heart valve disposed in the native valve annulus and in its deployed configuration, an anchoring tether can extending from the anchor can be secured to a wall of the heart to urge the anterior native leaflet towards the body of the prosthetic heart valve.

Apparatus and methods for anterior valve leaflet management

In some embodiments, an apparatus includes a catheter assembly and a handle assembly that can be removably coupled to the catheter assembly. A valve holding tube defines a lumen configured to receive a prosthetic mitral valve in a compressed configuration and can be removably coupled to a distal end portion of the handle assembly. The valve holding tube can be received within a hub of the catheter assembly when coupled to the handle assembly. The actuator when actuated is configured to cause the tensioning unit to travel along a traveler strap of the catheter assembly moving the handle assembly distally such that a distal end of an elongate shaft of the handle assembly moves the prosthetic mitral valve distally out of the valve holding tube and out a distal end of the sheath such that the prosthetic mitral valve is free to move to a biased expanded configuration.

Apparatus and methods for delivery of transcatheter prosthetic valves

A vascular closure device includes an anchor, a suture carrying portion, and at least three needles. The anchor is positionable through a vessel puncture in a vessel wall and operable between expanded and retracted positions. The suture carrying portion is positioned distal of the anchor and configured to carry at least one suture. The needles are operable between an advanced position extending through the vessel wall adjacent to the vessel puncture to connect to the at least one suture, and a retracted position in which the needles position the at least one suture through the vessel wall. The needles and sutures are configurable to close large bore openings in the vessel wall.

Three suture large bore closure device and methods

In some embodiments, a method for transfemoral retrieval and/or repositioning of a prosthetic valve () implanted within a heart includes inserting a retrieval assembly through a femoral vein and into a heart until a distal end portion of the retrieval assembly is disposed in an atrium of the heart. The prosthetic valve is formed with a shape-memory material. The retrieval assembly () includes an outer catheter (), a middle catheter (), a snare catheter (), and a snare member (). The snare member is moved distally out of a lumen of the snare catheter and into engagement with an inner frame () of the prosthetic valve. The retrieval assembly can invert an outer frame () of the prosthetic valve to collapse and retract the valve into a lumen of the retrieval assembly. In some embodiments, a positioning catheter () can be inserted through the apex of the heart to assist in positioning and inverting the prosthetic valve.

Apparatus and methods for trans-septal retrieval of prosthetic heart valves

Growing community of inventors

Minneapolis, MN, United States of America

Zachary J Tegels