Ignyta, Inc.

Boundless Bio, Inc.

Zachary Dolph Hornby

Christian Andreus Hassig

Gang Li

Deepti Wilkinson

Kristen Turner

Ryan Hansen

Snezana Milutinovic

Jason Christiansen

Sudhir Chowdhry

Anthony Celeste

Garrett M Brodeur

David Wesley Anderson

Radhika Iyer

Ge Wei

Jonathan Ee-ren Lim

Provided herein are methods of treating cancer in a subject, wherein the cancer is extrachromosomal DNA-positive (ecDNA-positive) or therapeutically resistant, the method comprising administering to the subject a therapeutically effective amount of a replication stress (RS) pathway agent alone or in combination with a targeted therapeutic.

Replication stress pathway agent compositions and methods for treating cancer

Described herein are combinations comprising a therapeutically effective amount of a first agent and a therapeutically effective amount of a second agent, wherein the first agent is an inhibitor of ALK, ROS1, TrkA, TrkB, or TrkC activity, or a combination thereof, and methods of using such combinations in the treatment of patients having cancer.

Combinations for the treatment of cancer

Disclosed are methods of treating neuroblastoma in a cancer patient by administration of a Trk inhibitor in combination with one more chemotherapeutic agents. Also disclosed are pharmaceutical compositions comprising a Trk inhibitor and one or more chemotherapeutic agents.

Combinations for the treatment of neuroblastoma

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San Diego, CA, United States of America

Zachary Dolph Hornby