Saint Louis University

Zachary Buchwald

Rajeev Aurora

Jennifer Kiesel

Systems and methods for inhibiting bone loss using FoxP3+ CD8 T-cells (Tc). Osteoclasts are induced to produce FoxP3+ CD8 T-cells (Tc) through introduction of a low-dose of a RANK agonist such as RANKL. The RANKL was found to best work when provided in accordance with a schedule resulting in a pulsed administration.

Suppression of bone loss by introducing FoxP3+ CD8 T-cells (TcREG)

Systems and methods for inhibiting bone loss using FoxP3+ CD8 T-cells (Tc). Osteoclasts are induced to produce FoxP3+ CD8 T-cells (Tc) either in vivo or ex vivo. The FoxP3+ CD8 T-cells (Tc) are provided to the patient to subsequently regulate osteoclast function, thereby establishing a bi-directional regulatory loop between osteoclasts and FoxP3+ CD8 T-cells (Tc).

Growing community of inventors

St. Louis, MO, United States of America

Zachary Buchwald