Phenex Pharmaceuticals Ag

Phenix Pharmaceuticals Ag

Zach Cheruvallath

John S Kiely

Claus Kremoser

Ronnie C Hanecak

Elena Dneprovskaia

Ulrich Deuschle

Kerstin Otte

Normand Hébert

Ulrike Bauer

Ingo Kober

Manfred Kögl

Harald Kranz

Matthew Lee

Tim Gahman

Carlton Sage

Kristina Giegrich

Manish Sud

The invention provides compounds according to the general formula () which bind to the NRHreceptor and act as agonists, antagonists or mixed agonists/antagonists of the NRHreceptor. The invention further provides methods of treating diseases and/or conditions through binding of the nuclear receptor by the compounds and the production of medicaments using the compounds.

FXR NR1H4 nuclear receptor binding compounds

The present invention relates to compounds according to the general formula (I) which bind to the nuclear receptor, NR1H4, and act as agonists and antagonists of the NR1H4 receptor. The invention further relates to the treatment of diseases and/or conditions through binding of the nuclear receptor by the compounds.

NR1H4 nuclear receptor binding compounds

The present invention relates to compounds according to the general formula (I) which bind to the NR1H4 receptor and act as agonists of the NR1H4 receptor. The invention further relates to the treatment of diseases and/or conditions through binding of the nuclear receptor by the compounds and the production of medicaments using the compounds.

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San Diego, CA, United States of America

Zach Cheruvallath