Depuy Orthopaedics, Inc.

Depuy Products, Inc.

Z David Deng

Todd P Glancy

Dale R Peterson

Robson F Storey

Samuel I Stupp

Gerry Sigler

Methods for tissue repair are provided employing a matrix comprising a biocompatible, bioerodable polymer, said polymer comprising a thermoplastic lactide-containing terpolymer of monomer units derived from lactic acid, glycolic acid, and either caprolactone or valerolactone, which has a water solubility of about 0.01 to about 500 mg/mL at about 25&#xb0; C. and adhesive strength of about 600 to about 150,000 Pa and applying the matrix to a tissue defect. The matrix or adhesive can further comprise a filler or a bioactive agent, or both.

Bioerodable polymeric adhesives for tissue repair

Improved matrices and adhesives for tissue repair comprising a biocompatible, bioerodable polymer, said polymer comprising a thermoplastic lactide-containing terpolymer of monomer units derived from lactic acid, glycolic acid, and either caprolactone or valerolactone, which has a water solubility of about 0.01 to about 500 mg/mL at about 25&#xb0; C. and adhesive strength of about 600 to about 150,000 Pa. The matrix or adhesive can further comprise a filler or a bioactive agent, or both.

Methods for tissue repair are provided employing a matrix comprising a biocompatible, bioerodable polymer, said polymer comprising a thermoplastic lactide-containing terpolymer of monomer units derived from lactic acid, glycolic acid, and either caprolactone or valerolactone, which has a water solubility of about 0.01 to about 500 mg/mL at about 25&deg; C. and adhesive strength of about 600 to about 150,000 Pa and applying the matrix to a tissue defect. The matrix or adhesive can further comprise a filler or a bioactive agent, or both.

The present invention is directed to a biocompatible tissue reactive composition comprising a functionalized polymer having tissue reactive substituents that are capable of forming covalent bonds with tissue associated functional groups.

Tissue reactive adhesive compositions

Improved matrices for tissue repair comprising a biocompatible, bioerodable polymer which has a water solubility of about 0.01 to about 500 mg/mL at about 25&deg; C. and adhesive strength of about 600 to about 150,000 Pa; and pressure sensitive adhesives for tissue repair which have adhesive strength of about 600 to about 150,000 Pa. The matrix or adhesive can further comprise a filler or a bioactive agent, or both. The matrices and adhesives are tissue-adherent and dough-like so they can be molded to fit a repair site. When used for bone/implant fixation, or as a filler for bone or cartilage repair, gradual short-term bioerosion of the adhesive matrix allows it to be replaced with developing bone or cartilage tissue. When used for release of a bioactive agent, the agent can be mixed into the adhesive matrix well before the implantation procedure. After implantation, the bioactive agent is gradually released as the adhesive matrix biodegrades.

Biodegradable poly(ester-anhydrides) designed to display two-stage degradation profiles are described. The presence of the anhydride linkages allows a relatively rapid decrease in molecular weight, the extent of which is governed by the concentration of the anhydride linkages along the chain, followed by possible dissolution and a slower degradation of the remaining oligomers, the rate of which is governed by the composition of the polyester prepolymers. Methods for the preparation of the poly(ester-anhydrides) and their polyester precursors are also described.

Poly (ester-anhydrides) and intermediates therefor

Carboxy-terminated polyester ionomers useful for bioresorbable implant construction are described. They comprise biocompatible salts or partial salts of mono- or bis-carboxy-terminated polyesters.

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Carmel, IN, United States of America

Z David Deng