Wisconsin Alumni Research Foundation

Yvonne M Angell

Daniel H Rich

Miroslav Malkovsky

Prakash Raman

The present invention relates generally to cyclosporin analogs, and more paritcularly to methods for the solid-phase synthesis and on-resin cyclization of cyclosporin analogs. Methods are described for the on-resin cyclization of sterically hindered compounds synthesized through solid phase synthesis techniques. The methods utilize solvent, temperature, and washing conditions that allow the efficient on-resin cyclization of compounds like analogs of cyclosporin A.

Solid phase synthesis of immunosuppressive agents

Compositions and methods are described for the synthesis of novel analogs of cyclosporin A, and the use of those analogs as immunostimulatory agents.

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Madison, WI, United States of America

Yvonne M Angell