Astrazeneca Ab

Yvonne Lo-Alfredsson

Donald Pivonka

Anders Bogevig

Anna-Karin Tidén

Anders Bögevig

Donald Astrazeneca Wilmington Pivonka

There are disclosed novel compounds of formula (I) wherein R, R, L, X and Y are as defined in the specification, and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of the enzyme MPO and are thereby particularly useful in the treatment or prophylaxis of neuroinflammatory disorders, cardiovascular disorders and respiratory disorders.

Pyrrolo[3,2-D]pyrimidin-4-one derivatives and their use in therapy

There are disclosed novel compounds of formula (I) wherein R, R, L, X and Y are as defined in the specification, and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of the enzyme MPO and are thereby particularly useful in the treatment or prophylaxis of neuroinflammatory disorders, cardiovascular disorders and respiratory disorders. 

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Sodertalje, Sweden

Yvonne Lo-Alfredsson