Jasco Pharmaceuticals, LLC

Yvonne L Flanders

Stephane A Dumas

Carmen M Baldino

Justin L Caserta

Chee-Seng Lee

Robert B Nicewonger

Disclosed are compounds, pharmaceutical compositions containing those compounds, and uses of the compounds and compositions as modulators of CK1, CK1&#x3b3;1, CK1&#x3b3;2, CK1&#x3b3;3, CK2, Pim 1, Pim2, Pim3, the TGF&#x3b2; pathway, the Wnt pathway, the JAK/STAT pathway, the AKT pathway, and/or the mTOR pathway. Uses are also disclosed for the treatment or prevention of a range of therapeutic indications due at least in part to aberrant physiological activity of CK1, CK1&#x3b3;1, CK1&#x3b3;2, CK1&#x3b3;3, CK2, Pim 1, Pim2, Pim3, the TGF&#x3b2; pathway, the Wnt pathway, the JAK/STAT pathway, the AKT pathway, and/or the mTOR pathway.

Aminopyrimidine kinase inhibitors

Disclosed are compounds, pharmaceutical compositions containing those compounds, and uses of the compounds and compositions as modulators of casein kinase 1 (e.g., CK1&#x3b3;), casein kinase 2 (CK2), Pim1, Pim2, Pim3, the TGF&#x3b2; pathway, the Wnt pathway, the JAK/STAT pathway, and/or the mTOR pathway. Uses are also disclosed for the treatment or prevention of a range of therapeutic indications due at least in part to aberrant physiological activity of casein kinase 1 (e.g., CK1&#x3b3;), casein kinase 2 (CK2), Pim1, Pim2, Pim3, the TGF&#x3b2; pathway, the Wnt pathway, the JAK/STAT pathway, and/or the mTOR pathway.

Disclosed are compounds, pharmaceutical compositions containing those compounds, and uses of the compounds and compositions as modulators of casein kinase 1 (e.g., CK1&#x3b3;), casein kinase 2 (CK2), Pim-1, Pim-2, Pim-3, the TGF&#x3b2; pathway, the Wnt pathway, the JAK/STAT pathway, and/or the mTOR pathway. Uses are also disclosed for the treatment or prevention of a range of therapeutic indications due at least in part to aberrant physiological activity of casein kinase 1 (e.g., CK1&#x3b3;), casein kinase 2 (CK2), Pim-1, Pim-2, Pim-3, the TGF&#x3b2; pathway, the Wnt pathway, the JAK/STAT pathway, and/or the mTOR pathway.

Disclosed are compounds, pharmaceutical compositions containing those compounds, and uses of the compounds and compositions as modulators of casein kinase 1 (e.g., CK1&#x3b3;), casein kinase 2 (CK2), Pim 1, Pim2, Pim3, the TGF&#x3b2; pathway, the Wnt pathway, the JAK/STAT pathway, and/or the mTOR pathway. Uses are also disclosed for the treatment or prevention of a range of therapeutic indications due at least in part to aberrant physiological activity of casein kinase 1 (e.g., CK1&#x3b3;), casein kinase 2 (CK2), Pim 1, Pim2, Pim3, the TGF&#x3b2; pathway, the Wnt pathway, the JAK/STAT pathway, and/or the mTOR pathway.

Growing community of inventors

Medford, MA, United States of America

Yvonne L Flanders