Abbott Laboratories Corporation

Yvonne Connolly Martin

Jaroslav Kyncl

Anthony K Fung

Peter Hadley Jones

Amrit Lall

Biswanath De

John F DeBernardis

Richard J Perner

Michael D Meyer

David M Stout

Fatima Z Basha

Chi-nung W Hsiao

Dilbagh Singh Bariana

Carroll Wayne Ours

John W Kebabian

Robert W Schoenleber

Michael P DeNinno

Dilbagh S Bariana

Stanley DiDomenico, Jr

Kathleen Riley Lynn

Novel compounds which are selective dopamine agonists are useful for treating disorders characterized by abnormal dopamine levels, such as Parkinson's Disease, as well as cardiovascular disorders.

Dopamine agonists

This invention provides 4-aroyl substituted phenoxy acetic acids and tetrazoles of the formula ##STR1## wherein R is a phenyl ring, a substituted phenyl ring, or naphthyl; R.sub.1 is --CH.sub.2 COOH or methyl tetrazole, and X.sub.1 and X.sub.2 are each a halogen or loweralkyl, or when taken together form with the two attached carbons a phenyl ring. These compounds are useful as antihypertensive agents, diuretics and uricosuric agents.

4-Aroyl substituted phenoxy methylene-5-tetrazoles

4-Aroyl-substituted phenoxy acetic acids

Covers a .gamma.-glutamyl amide of dopamine selected from the group consisting of ##EQU1## and a pharmaceutically acceptable acid addition salt thereof. Also covers the use of said .gamma.-glutamyl amide to increase renal blood flow by administering said amide to warm-blooded mammals.

Compositions and methods of increasing renal blood flow with

Growing community of inventors

Waukegan, IL, United States of America

Yvonne Connolly Martin