American Home Products Corporation

Wyeth

Yvette L Palmer

Jerauld S Skotnicki

Michael G Kelly

Magid A Abou-Gharbia

Wenling Kao

Wayne Everett Childers

Gan Zhang

Edward J Podlesny

Lynne Padilla Greenblatt

Derek Cecil Cole

Annmarie Louise Sabb

Robert L Vogel

Steven Edward Lenicek

Byron Abel Bravo

Wenling Koa

A compound having 5-HTreceptor activity, represented by the chemical formula wherein: The invention also includes compositions containing such a compound, as well as methods for using a compound of the invention.

Pyridinyl-methyl-ethyl cyclohexanecarboxamides as serotonergic agents

This invention relates to compounds which have activity as 5-HTagonists and antagonists which may be useful for the treatment of anxiety, depression, cognitive deficits, and prostate cancer, having the formula wherein: X is a moiety selected from the group of: n is selected from the integers 1 through 5; Ris optionally substituted aryl or mono or bicyclic heteroaryl, with a proviso that heteroaryl is not thiadiazole; Ris H or alkyl; Ris H, COR, COOR, and CONRR; Ris H, alkyl, alkenyl, alkynyl, aryl, mono or bicyclic heteroaryl, aralkyl, and mono or bicyclic heteroaralkyl, wherein the aryl or heteroaryl groups are optionally substituted; Rand Rare H, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, adamantyl, and noradamantyl or Rand Rtaken together may form a 5&#x2013;7 membered azacyclic ring, optionally containing an additional heteroatom selected from O, S, or NR; when Ror Rare chosen from cycloalkyl or cycloalkenyl, the cyclic group may optionally be substituted at the 1-position with a C&#x2013;Calkyl group;or an optical isomer; or a pharmaceutically acceptable salt thereof.

Cycloalkyl-substituted aryl-piperazines, piperidines and tetrahydropyridines as serotonergic agents

The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of a disorder relating to or affected by the 5-HT6 receptor.

(1-substituted-indol-3-yl) alkylidenehydrazinecarboximidamide derivatives as 5-hydroxytryptamine-6 ligands

The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor.

Chroman and benzofuran derivatives as 5-hydroxytryptamine-6 ligands

Arylpiperidine and aryl-1,2,5,6-tetrahydropyridine amide derivatives

Piperazine ethylamide derivatives

Arylpiperidine and aryl-1,2,5,6-tetrahydropyidine amide derivates

N-substituted imide derivatives with serotonergic activity

1,4-piperazine derivatives

The present invention provides compounds of the general formula (1):

Diazole derivatives as serotonergic agents

A compound of the structure ##STR1## wherein R and R.sup.1 are each, independently, hydrogen, or ##STR2## R.sup.2 and R.sup.3 are each, independently, hydrogen, alkyl, alkenyl, alkynyl, --CO.sub.2 R.sup.5, --COR.sup.5, --CN, --NO.sub.2, --SO.sub.2 R.sup.5, --SO.sub.3 R.sup.5, --OR.sup.5, --SR.sup.5, or Ar;

Rapamycin amidino carbamates

A compound of the structure ##STR1## wherein R and R.sup.1 are each, independently, hydrogen, ##STR2## R.sup.2 and R.sup.3 are each, independently, hydrogen, alkyl, alkenyl, alkynyl, --CO.sub.2 R.sup.5, --COR.sup.5, --CN, --NO.sub.2, --SO.sub.2 R.sup.5, --SO.sub.3 R.sup.5, --OR.sup.5, --SR.sup.5, or Ar;

Carbamates of rapamycin

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Newtown, PA, United States of America

Yvette L Palmer