Centre National De La Recherche Scientifique

Yves-Michel Frapart-Jannuad

Joanna Bakala

Maria Conception Achab

Bernard Delpech

Bogdan Iorga

Pascal Collin

Fabienne Peyrot

Franck Pelissier

The present invention relates to a 3-aryl-4 catechol-pyrrole-n-propanol compound and the derivatives thereof having General Formula (I), wherein:&#x2014;Ris an aryl group, particularly a phenyl, optionally substituted by one or more (C-C)alkyl groups, one or more halogens, one or more &#x2014;OH, &#x2014;CN or CFgroups, or a combination of same, and&#x2014;Ris a (C-C)alkyl group, a hydroxy(C-C)alkyl group, a (C-C)alcoxy(C-C)alkyl group, or a pharmaceutically acceptable hydrate or solvate of same. The invention also relates to the methods for preparing said compound and derivatives, to the pharmaceutical compositions containing same, and to the use of same as a drug or in the form of a prodrug converted via dimerization, particularly via oxidative coupling in the presence of a superoxide anion, in the treatment of cancer and diseases related to excessive angiogenesis. 

Use of a novel 3-aryl-4-catechol-pyrrole-N-propanol compound and the derivatives thereof to treat cancer and diseases related to excessive angiogenesis

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Ecury sur Coole, France

Yves-Michel Frapart-Jannuad