Centre International De Recherches Dermatologiques

Yves M Darmon

Braham Shroot

Philippe Nedoncelle

Bruno C Bernard

Claude Martin

4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl) benzoic acid marked with tritium is used as a radioactive marker in the titration of nuclear receptors and CRABP, in the measurement of the affinity of retinoids for nuclear receptors and CRABP, in the titration of known retinoids, the characterization of antibodies directed against 4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl) benzoic acid, and in the study of the distribution and metabolism of said benzoic acid derivative.

Compound marked with tritium, its preparation and its use in particular

A protein characterized by the fact that it is a nonkeratinic protein present in the cytoplasm of suprabasal epidermal cells, in particular in man, and absent in basocellular carcinoma, melanoma and naevus cells; antibodies directed against said protein, their preparation and their application as reagents; cellular stocks secreting such antibodies, and their preparation.

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Antibes, France

Yves M Darmon