Institut National De La Sante Et De La Recherche Medicale

Centre National De La Recherche Scientifique

Bristol-myers Squibb Compnay

E. R. Squibb Sons, Inc.

Université Louis Pasteur

Université Louis Pasteur Strasbourg I

Yves Lutz

Pierre H Chambon

Hinrich Gronemeyer

Johannes Voegel

Michael Saunders

Cecille Rochette-Egly

Marc Mousli

Christian Bronner

Isabelle Scheuer

Jean-Marc Jeltsch

Marie-Pierre Gaub

Raphaël Hopfner

Pierre Oudet

Rapha¬l Hopfner

The invention concerns a novel ICBP90 (Inverted CCAAT box binding protein 90) and its fragments, polynucleotides coding for said polypeptides and specific antibodies directed against said polypeptides. The invention also concerns methods and kits for diagnosing cell proliferation and compounds useful as medicine for preventing and/or treating pathology involving cell proliferation and in particular cancer.

ICBP90 polypeptide and its fragments and polynucleotides coding for said polypeptides and applications for diagnosing and treating cancer

The present invention concerns a nuclear receptor (NR) transcriptional mediator. More specifically, isolated nucleic acid molecules are provided encoding transcriptional intermediary factor-2 (TIF2). Recombinant methods for making TIF2 polypeptides are also provided as are TIF2 antibodies. Screening methods are also provided for identifying agonists and antagonists of the activation function AF-2 of nuclear receptors, for identifying agonists and antagonists of the AD1 activation domain activity of TIF2, and for identifying agonists and antagonists of the AD2 activation domain activity of TIF2.

Transcriptional intermediary factor-2

The present invention discloses methods for preparing antibodies which bind to specific isoforms of the human retinoic acid receptor-.gamma. (RAR-.gamma.). In addition, several monoclonal antibodies are described which bind to human RAR-.gamma., but not to mouse or which bind to RAR-.gamma.1, but not to RAR-.gamma.2. Methods and kits are described which allow one to detect the isotype of RAR-.gamma. which is expressed in a test sample. Such methods are useful in determining the tissue specific pattern of expression of various RAR-.gamma. isoforms.

Antibodies specific for retinoic acid receptor-.gamma.

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Strasbourg, France

Yves Lutz