Agence Nationale De Valorisation De La Recherche (anvar)

Agence Nationale De Valorisation De La Recherche

Yves Langlois

Nicole Langlois

Pierre Potier

Pierre Mangeney

Ratremaniaina Z Andriamialisoa

Francoise Gueritte

Pierre Potieo

The present invention relates to a process for the preparation of bis-indolic compounds, and the bis-indolic compounds produced by the process.

Bis-indolic compounds

Process for the preparation of bis-indolic compounds

The invention relates to new chemical compounds. They are compounds corresponding to formula Ia. ##STR1## in which: R'.sub.3 represents a hydrogen atom or a hydroxy radical; R'.sub.5 represents a hydrogen atom or a hydroxy radical; or R'.sub.3 and R'.sub.5 together represent an epoxy bridge or a double bond; R'.sub.5 represents a hydrogen atom or an ethyl radical; R'.sub.7 and R'.sub.8 are the same or different and represent a hydrogen atom or a methyl, hydroxymethylene, alkoxymethylene, aryloxymethylene, aminomethylene, monoalkyl or dialkyl aminomethylene, acylmethylene, arylaminomethylene, hydroxyethyl aminomethylene, alkylthiomethylene, aryloxythiomethylene or cyanomethylene radical; R.sub.1 represents a hydrogen atom or an alkyl, formyl or acyl radical: R.sub.2 represents a hydrogen atom or an alkoxy radical; R.sub.7 represents an alkanoyloxy radical, the broken line representing an optional double bond. These compounds can be used as drugs.

Class of seco bis-indolic compounds which can be used as drugs and a

A process for the preparation of a compound of formula (V) and salts thereof ##STR1## wherein R.sub.1 is selected from the group consisting of a hydrogen atom, an alkyl radical, a formyl radical and an acyl radical;

Process for the synthesis of leurosine and of its derivatives

Compounds with antitumoral activity corresponding to the formula (I): ##STR1## wherein R'.sub.1 is a hydrogen atom or an alkoxy, acyl, formyl or haloacyl radical; R'.sub.2 is a hydrogen atom or an alkyl radical; R'.sub.3 and R'.sub.3 are a hydrogen atom, hydroxyl radical or an alkanoyloxy radical, and together are a carbonyl group, and R'.sub.3 and R'.sub.5 together are an epoxy bridge or a double bond; R'.sub.4 is a hydrogen atom or an alkyloxycarbonyl, hydroxymethyl, alkanoyloxymethyl or acetamido radical; R'.sub.5 and R'.sub.5 are a hydrogen atom or a hydroxyl, alkanoyloxyl, ethyl or 2-hydroxyethyl radical; R'.sub.6 is a hydrogen atom or an ethyl, 2-hydroxyethyl or acetyl radical; R.sub.1 is a hydrogen atom or an alkyl, formyl or acyl radical; R.sub.2 is a hydrogen atom or alkoxy radical; R.sub.3 is a hydrogen atom or a hydroxyl or alkanoyloxyl radical, and together with R.sub.4 is an epoxy bridge or a double bond; R.sub.4 is a hydrogen atom or a hydroxyl, alkanoyloxyl radical, and together with R.sub.5 is an epoxy bridge; R.sub.6 is an alkyloxycarbonyl, hydrazido, acetamido, hydroxymethyl or alkanoyloxymethyl radical; and R.sub.5 and R.sub.7 are a hydrogen atom or a hydroxyl and alkanoyloxyl radical; acid addition and quaternary ammonium salts thereof and 12-chloro derivatives thereof.

Nor bis-indole compounds usable as medicaments

The invention provides a process for the preparation of leurosidine or vinblastine, which comprises hydroxylating and reducing .DELTA..sup.20' dehydroxy-20' vincaleucoblastine corresponding to formula (II): ##STR1##

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Bures S. Yvette, France

Yves Langlois