Symphar S.a.

Smithkline Beecham Corporation

Ilex Products, Inc.

Yves Guyon-Gellin

Eric Joseph Niesor

Craig Leigh Bentzen

Hieu Trung Phan

Lan Mong Nguyen

Robert John Ife

Vinh Van Diep

Raymond Azoulay

Simon Floret

Alexandre Bulla

Lan Nguyen Mong

Kyriacos Kalathakis

Jean-Robert Rossier

Aminophosphonates alpha substituted by phenol groups of formula (I) have lipoprotein(a) lowering activity.

Compounds and pharmaceutical compositions containing them

The present invention relates to novel aminophosphonate derivatives substituted in .alpha. position by phenol groups, of formula (I): ##STR1## in which: X.sup.1, X.sup.2, X.sup.3, R.sup.1, R.sup.2, A, B, Z and n are defined in claim 1, as well as their preparations and the pharmaceutical compositions comprising them.

Substituted aminophosphonate derivatives, process for their preparation

2-Substituted-1,3-propylidenediphosphonates of formula (I), where A, R.sup.1 and R.sup.2 are defined in claim 1, are therapeutically active compounds, namely for the treatment of cardiovascular diseases. They can be prepared by reacting phosphonating agents with 1,3- dibromopropanes or ditosylates of 1,3-propanediols substituted in position 2. ##STR1## .

Certain 2-substituted 1,3-propylidenediphosphonate derivatives,

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Geneva, Switzerland

Yves Guyon-Gellin