Adir Et Compagnie

Les Laboratoires Servier

Les Laboratories Servier

Yves Charton

Claude Guillonneau

Pierre Lestage

Brian Lockhart

Solo Goldstein

Alain Pierre

Gilbert Regnier

Ghanem Atassi

Jacques Duhault

Emile R Bisagni

Nicolas Guilbaud

Joseph Espinal

Emmanuel Canet

Michel Lonchampt

Stephane Leonce

A compound selected from those of formula (I): wherein: Medicinal products containing the same which are useful in the treatment of conditions requiring a specific nicotinic ligand of &#x3b1;4&#x3b2;2 receptors.

Polysubstituted 1,1-pyridylaminocyclopropanamine compounds

Polysubstituted 1,1-pyridyloxycyclopropanamine compounds

A compound selected from those of formula (I):wherein:

1,1- and 1,2-disubstituted cyclopropane compounds

The compounds of formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8 and A are as defined in the description, their optical isomers and N-oxides, and pharmaceutically acceptable addition salts thereof with an acid or base, and the use thereof as anti-tumor agents.

Ellipticine compounds

A compound of formula (I): ##STR1## wherein Ra represents linear or branched (C.sub.1 -C.sub.8)alkylene,

1,2-dithiolane compounds

Compounds of the formula: ##STR1## in which R.sub.1, R.sub.2, A and B are as defined in the description, their optical isomers, N-oxides and addition salts with a phar-maceutically acceptable acid, and their use as anti-tumor agents.

Bis-pyrido�4,3-b!carbazole compounds

The compounds of formula: ##STR1## in which: R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and A are as defined in the description, their optical isomers and N-oxides and addition salts thereof with a pharmaceutically acceptable acid or base, and their use as anti-tumour agents.

The invention provides new compounds pertaining to the class of: aryl methoxy phenyl alkyl heterocyclic spiro compounds, enantiomers, diastereoisomers and physiologically-tolerable salts thereof. For example: 8-{2-�3-quinol-2-yl methoxy)phenyl!ethyl}-3,8-diaza-1-oxa-2-oxo spiro�4,5!decane is described. Medicinal products containing the same are useful in the treatment of any pathology involving modifications of leukotriene metabolism.

Heterocyclic spiro compounds

The compounds are 5-(4-substituted benzyl)thiazolidine-2,4-diones, enantiomers, diastereoisomers and pharmaceutically tolerable salts thereof, useful for treating conditions of insulin-resistance and/or non insulin-dependent diabetes. A compound disclosed is: .(R,S)-5-{4-[2-benzofuran-2-yl)carbonylamino)ethyl]benzyl}thiazolidine-2,4 -dione.

Thiazolidinedione compounds

The compounds are 5-(4-substituted benzyl)thiazolidine-2,4-diones, enantiomers, diastereoisomers and pharmaceutically tolerable salts thereof, useful for treating conditions of insulin-resistance and/or non insulin-dependent diabetes. A compound disclosed is: 5-{4-[2-(2-methoxy-5-chlorobenzamido)ethyl]benzyl}thiazolidine-2,4-dione.

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Sceaux, France

Yves Charton