Hitachi, Ltd.

Hitachi Koki Co., Ltd.

Roche Diagnostics Operations, Inc.

Hitachi High-tech Corporation

Showa Denko Materials Co., Ltd.

Roche Diagnostics Gmbh

F. Hoffmann-la Roche Ag

Yuzuru Shimazaki

Tatsuo Nakagawa

Junko Tanaka

Kunio Harada

Takao Kumasaka

Hiroshi Yoshida

Masahiko Ogino

Teruaki Mitsuya

Taku Sakazume

Akihiro Miyauchi

Shigeru Matsuyama

Takao Umeda

Toru Miyasaka

Chihiro Uematsu

Yukio Otome

Tatsuo Igawa

Isamu Komatsu

Shinya Matsuoka

Ken Sasaki

Keisuke Shibuya

Shigetaka Fujiwara

Takao Miyashita

Daisuke Ebihara

Masashi Maruyama

Mikio Konno

Ryuta Washiya

Yoshio Kobayashi

Nanae Yamashita

Akiko Shiratori

The present disclosure provides a technique capable of manufacturing a measurement cell having a high specimen utilization ratio in the case of using a measurement cell that introduces a specimen into a surface hole. In the measurement cell manufacturing method according to the present disclosure, a measurement cell includes a channel wall protruding from the lower surface substrate toward the through-hole, and a specimen solution is introduced into a lower surface side space to introduce the specimen into the through-hole.

Measurement cell manufacturing method and measurement cell

A digital PCR measuring apparatus capable of measuring a melting curve with high accuracy is provided. The digital PCR measuring apparatus includes a temperature adjuster that controls a temperature of a sample container including a plurality of minute regions, a fluorescence measurement part that measures fluorescence intensity of a plurality of minute regions, and a controller that controls the temperature adjuster and the fluorescence measurement part. The controller controls the temperature adjuster to raise a temperature of the sample container, and, after removing air bubbles generated in the sample container, measures fluorescence intensity of a plurality of minute regions while controlling the temperature adjuster to lower the temperature of the sample container, and measures a melting curve of a plurality of the minute regions.

Digital PCR measuring device

The present invention addresses the problem of providing a novel digital PCR analysis method. One embodiment of the novel digital PCR analysis method is a DNA detection method including the steps of: partitioning a DNA solution containing a fluorescent-labeled probe or a DNA intercalator and a target DNA to be detected into a plurality of compartments; carrying out a nucleic acid amplification reaction in the compartments; measuring a fluorescence intensity in association with a temperature change; calculating a melting temperature of a DNA double strand based on a change in the fluorescence intensity in association with the temperature change; and calculating a ratio of a fluorescence intensity at a second temperature that is lower than a first temperature in association with the temperature change to that at the first temperature.

Method and device for digital PCR measurement

Provided is an automatic analysis technique that prevents liquid contained in a reaction container from locally contacting with liquid added afterward and has less occurrence frequency of equipment malfunction and high performance. An automatic analyzer () includes: a reaction container disk () that holds a reaction container (); a stirring mechanism () that stirs liquid contained in the reaction container () in a non-contact manner; a carrying mechanism () that carries the reaction container () between the reaction container disk () and the stirring mechanism (); a reagent disk () that holds a reagent container (); and a reagent dispensing mechanism () that suctions and discharges a reagent contained in the reagent container (), the stirring mechanism () is provided at a position where the reagent dispensing mechanism () discharges the reagent, and the reagent dispensing mechanism () discharges the reagent, which is sucked from the reagent container (), to the reaction container () installed in the stirring mechanism ().

Automatic analyzer and analysis method

An object of the present invention is to provide an adsorbent material having high dispersibility and reversibility. The adsorbent material has a polymer material having a plurality of functional groups ionizable in water and exhibiting no lower limit critical solution temperature, an adsorption site capable of interacting with a target substance, and a carrier.

Adsorbent material

The present invention is characterized in that a filter made of resin comprises a through-hole film portion (); and a structure reinforce portion (), wherein a through-hole () is provided in a through-hole film portion (), the thickness of the through-hole film portion () is from 0.5 to 2.0 &#x3bc;m, the bore of the through-hole () is from 0.05 to 0.5 &#x3bc;m, the thickness of the structure reinforce portion () is bigger than the thickness of the through-hole film portion (), the structure reinforce portion () encloses the through-hole film portion (), a damage-reduction structure is provided on the upper surface of the structure reinforce portion (), and wherein, the damage-reduction structure may be an uneven structures.

Filter and method of the same

Although nanoparticles capable of providing an extremely large active surface area have highly marked advantages, when a PEFC electrode utilizing nanoparticles is used for a prolonged period of time, the catalyst nanoparticles on carrier of the PEFC electrode because of the nano-size thereof migrate and aggregate together to result in a rapid loss of activity. Thus, there is a demand for inhibition of the above aggregation so as to prevent any drop of catalytic activity. According to the present invention the aggregation of nanoparticles can be inhibited by catalyst nanoparticles containing Pt wherein a porous matter containing an inorganic oxide is disposed on the surface of the catalyst nanoparticles. When use is made of nanoparticles whose surface has undergone specific modification, excellent activity can be realized. Therefore, there are provided surface-modified nanoparticles and catalyst and further a PEFC electrode utilizing these nanoparticles.

Catalyst nanoparticle

Each of a charging process on and after a second time is carried out by a charging means having a controlling electrode. The relationship between a controlling potential (Vg) applied to the controlling electrode of each charming means, the target surface potential (Vo) of a non-image portion of a surface of a photosensitive body and the direct current component potential (Vdc) of a developing bias potential in each developing process is satisfied by the formula, which is .vertline.Vo.vertline.&gt;.vertline.Vdc.vertline..gtoreq..vertline.Vg.vertlin e.. Thereby the corona current ia supplied to flow sufficiently, it can rise the surface potential of a toner image portion of the surface of the photosensitive body after the re-charming without the excessive rise of the surface potential of the non-image portion of the photosensitive body. The surface potential of the toner image portion of the photosensitive body after the re-charging becomes to higher than the direct component potential (Vdc) of the developing bias potential, it can prevent from mixing the toners having other color.

Method of multi-color recording using electro-photography process and

Non-contact type developing device and method for electrophotographic recording system. The pitch of magnetic poles on a developing sleeve carrying a developer is selected to fall within a predetermined range or is varied such that the pitch increases as the circumferential distance from the point where the gap between the developer carrier member and a photosensitive member is minimum. The bias voltage applied to the developing sleeve is controlled in accordance with a change in the size of the gap between the surface of the photosensitive member and the layer of the developer on the developer carrying member. Alternatively, the bias voltage is applied throughout a period in which the charged region on the photosensitive member is opposed by the developing sleeve.

Electrophotographic recording method and apparatus with non-contact

In a display panel consisting essentially of a pair of substrates whose opposed surfaces are equipped with transparent conductive layers and at least one of which consists of an organic polymer film, and of a display member interposed between said pair of substrates, the improvement wherein said organic polymer film is a uniaxially stretched polyester film.

Display panel having uniaxially-stretched organic polymer film as the

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Tokyo, Japan

Yuzuru Shimazaki