Central Glass Company, Limited

Yuzuru Morino

Akihiro Ishii

Satoru Narizuka

Mikihiro Takahashi

Takashi Kume

Hideyuki Tsuruta

Michio Ishida

Makoto Koide

Masaki Fujiwara

Yoshiyuki Kikuchi

Shinya Akiba

Yasunobu Nishimura

Seiji Hasegawa

Toshihiro Nakamichi

Masaaki Takeda

Shigeru Fujii

Tishihiro Nakamichi

Disclosed is a method for producing a hexafluoroisopropanol, including the steps of (a) purifying a mixture containing hexafluoroacetone and at least 1,1,1-trifluoro-2,2-dichloroethane as an impurity, thereby obtaining a purified hexafluoroacetone containing 120 ppm or lower of the 1,1,1-trifluoro-2,2-dichloroethane; and (b) bringing hydrogen (H) into contact with the purified hexafluoroacetone in the presence of a catalyst, thereby hydrogenating the hexafluoroacetone into the hexafluoroisopropanol. It is possible by this method to produce the hexafluoroisopropanol with a short reaction time and a high conversion. Therefore, it is possible to particularly advantageously produce fluoromethyl hexafluoroisopropyl ether (sevoflurane) by using the hexafluoroisopropanol produced by the method.

Method for producing hexafluoroisopropanol and fluoromethyl hexafluoroisopropyl ether (sevoflurane)

Disclosed is a purification method of reducing and removing fluoride ions contained in an optically active &#x3b1;-fluorocarboxylic acid ester represented by formula [1] [in the formula, Rrepresents a Calkyl group, Rrepresents a Calkyl group, and * represents an asymmetric carbon], the purification method of the optically active &#x3b1;-fluorocarboxylic acid ester being characterized by that a distillation is conducted in the presence of an organic base. By this method, it is possible to greatly reduce the concentration of fluoride ion traces contained in the optically active &#x3b1;-fluorocarboxylic acid ester by a relatively easy operation. Of the organic base, a tertiary amine is preferable, and above all tri-n-butylamine is particularly preferable.

Method for purification of optically active &#x3b1;-fluorocarboxylic acid esters

An optically active &#x3b1;-fluorocarboxylate is produced by reacting an optically active &#x3b1;-hydroxycarboxylate with sulfuryl fluoride (SOF), trifluoromethanesulfonyl fluoride (CFSOF) or nonafluorobutanesulfonyl fluoride (CFSOF) in the presence of organic base and in the absence of reaction solvent. More preferably, a distillation purification is conducted after adding acid to the reaction-terminated liquid. With this, it is possible to produce an optically active &#x3b1;-fluorocarboxylate of a still higher purity. It is possible by this process to advantageously produce an optically active &#x3b1;-fluorocarboxylate on a large-amount scale.

Process for producing optically active &#x3b1;-fluorocarboxylate

A method of producing benzamides represented by the following general formula (1):

Method of producing benzamides

The invention relates to a method for producing a benzoic acid derivative represented by the general formula (1). The method includes the step of reacting an aromatic compound represented by the general formula (2), with carbon monoxide and a hydroxy compound (i.e., water or an alcohol), in the presence of (a) a metal compound containing a metal of 8, 9 and 10 groups of periodic table, (b) a first phosphine derivative represented by the general formula (R,),P&mdash;Q&mdash;P(R,),, and (c) a base,

Method for producing benzoic acid derivatives

The invention relates to a method of preparing 2-chloro-pyridinemethanol represented by the following formula (1). The method includes the steps of: (a) reacting 2-chloro-monochloromethylpyridine with an alkali metal salt of a carboxylic acid and/or a hydrate of the alkali metal salt so as to form an ester derivative; and (b) hydrolyzing the ester derivative so as to form the 2-chloro-pyridinemethanol. ##STR1##

Method of preparing 2-chloro-pyridinemethanol

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Ube, Japan

Yuzuru Morino