Kyowa Hakko Kogyo Co., Ltd.

Senju Pharmaceutical Co., Ltd.

Yuzuru Ishimura

Hiromichi Suzuki

Tadashi Yoshida

Hideharu Anazawa

Kenichi Yoshida

Seiji Sugimoto

Makoto Suematsu

Tatsuo Suda

Shu Wakino

Takao Saruta

Toshiaki Monkawa

Matsuhiko Hayashi

Toshimasa Shinki

Hiroko Shimada

25-hydroxyvitamin D3-1&agr;-hydroxylase and DNA encoding the hydroxylase

This invention provides a hepatic graft preservative composition containing a phosphoric acid diester compound of the formula: ##STR1## (wherein R.sub.1 and R.sub.2 are the same or different and each represents a hydrogen atom or a methyl group) or a pharmacologically acceptable salt thereof and a method for viable preservation of the hepatic graft using the above substance. The hepatic graft preservative composition and hepatic graft preserving method of this invention inhibit hepatic microcirculation disturbance following cold storage-reperfusion of the liver to effectively prevent necrosis of hepatocytes and is, therefore, useful for the preservation of the hepatic graft.

Method for preserving a liver by perfusion with or storage in a solution

Growing community of inventors

Mitaka, Japan

Yuzuru Ishimura