Shiseido Company, Limited

Eth Zurich

Yuzo Yoshida

Tsutomu Soma

Michael Detmar

Kentaro Kajiya

Yosuke Tojo

Chieko Mizumoto

Masato Iino

Haruyo Yamanishi

Hisashi Mori

Yuko Matsuura

Shigeyoshi Fujiwara

Eriko Kawai

Yumiko Ishimatsu

The present disclosure relates to a serum-free medium for culturing of DS cells containing platelet derived growth factor (PDGF), or to a method for culturing of dermal sheath (DS) cells, using serum-free medium comprising PDGF.

Serum-free medium containing PDGF for DS cells

The purpose of the present invention is to develop a method for screening drugs having the effect of increasing skin barrier function in in vitro studies and to evaluate barrier function in the skin. Candidate drugs can be screened by using the activity and/or expression level of serine racemase as an indicator.

Method for screening agents promoting skin barrier function and method for evaluating skin barrier function taking epidermal serine racemase and/or D-serine level as indicator

The present invention relates to a method of evaluating cellulite using fibulin-3 and/or sarcoglycan gamma as an indicator in a harvested skin sample, and a method of evaluating a drug for improving, preventing or treating cellulite using fibulin-3 and/or sarcoglycan gamma as an indicator in cultured cells.

Method of evaluating cellulite and method of evaluating cellulite-effective drug using fibulin-3 and/or sarcoglycan gamma as an indicator

Provided is a method for regenerating hair follicles by transplanting a composition containing CD36-expressing dermal sheath cells (DSc) to a human. The composition may be prepared by sorting CD36-expressing dermal sheath cells from a hair follicle tissue by use of a cell-sorting technique along with an antibody to CD36. The composition may also contain dermal papilla cells (DPc).

Method for regenerating hair follicles using CD36-expressing dermal sheath cells

An object of the present invention is to promote hair growth or hair regeneration by promoting formation and/or regeneration of hair follicles. A method is provided for promoting formation and/or regeneration of hair follicles, comprising maintaining or increasing expression of one or a plurality of genes involved in cell adhesion in dermal papilla cells.

Method for promoting hair growth or hair regeneration by maintaining or increasing expression of cell-adhesion factor

The present invention relates to a plasminogen activator inhibitor, an external preparation for skin comprising the same, a method for improving rough skin and in particular, for improvement of an effective inorganic component. A plasminogen activator inhibitor contains a specific zinc oxide which adsorbs a plasminogen activator and effectively inhibits its activity. When it is used as an external preparation for skin, excellent improvement of rough skin is obtainable. Further, when silica-coated zinc oxide is applied as an external preparation for skin, excellent improvement effect and prevention effect for rough skin are obtainable without an intolerance sensitivity reaction in the case of morbid dermatitis such as atopic dermatitis or pimpled skin.

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Yokohama, Japan

Yuzo Yoshida