Asahi Kasei Kogyo Kabushiki Kaisha

Yuzo Yanagihara

Makoto Honda

Kohji Noguchi

Hiroshi Suzuki

An ion exchanger comprising a crosslinked copolymer and an ion exchange group, wherein an alcoholic hydroxyl group is bonded directly to the skeleton of a matrix of totally porous organic synthetic crosslinked copolymer. The ion exchanger has a predetermined hydroxyl group content, predetermined ion exchange group content, predetermined water regain value and predetermined specific surface area. The ion exchanger having a high mechanical strength and high chemical stability and not causing non-specific adsorption of bio-substances is useful as a high-speed liquid chromatography packing material and separating membrane, especially for bio-substances, such as protein, enzyme, peptide, amino acid, nucleotide or the like.

Ion exchanger having hydroxyl groups bonded directly to backbone skeleton

A granular crosslinked copolymer suitable as a high speed liquid chromatographic packing and especially as a gel permeation chromatographic packing is disclosed. In a preferred embodiment of the invention the packing is a copolymer essentially consisting of (I) units of at least one vinyl alcohol, (II) units of at least one vinyl ester of a carboxylic acid and (III) units of at least one crosslinking monomer having an isocyanurate ring, the ratio of the units (I) to the units (II) in the copolymer being within the range satisfying the following equation:

Isocyanurate-vinyl alcohol-vinyl ester chromatographic packing

Grains of a totally porous, hydroxyl group-containing, nonionic and hydrophilic synthetic cross-linked polymer having alcoholic hydroxyl and ether groups as main hydrophilic groups and having as a main skeleton a chemical structure including carbon atoms, hydrogen atoms and oxygen atoms bonded through single bonds, said synthetic polymer having a hydroxyl group density of 1 to 15 milliequivalents/g, a specific surface area of 5 to 1000 m.sup.2 /g and a water regain of 0.3 to 3.0 g/g. Such grains have been found to be a packing material or gel for high speed, aqueous gel permeation chromatography. The packing material of the present invention which comprises grains of a hydroxyl group-containing nonionic and hydrophilic synthetic cross-linked polymer has a chemical structure obtained by reacting a totally porous, hydroxyl group-containing, nonionic polymer with a polyfunctional substance capable of reacting with the hydroxyl groups of said polymer while forming cross-linking ether groups.

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Yokohama, Japan

Yuzo Yanagihara