Meiji Seika Kaisha, Ltd.

Yuzo Kazuno

Takashi Tsuruoka

Shigeharu Inouye

Taro Niida

Takashi Shomura

Harumi Fukuyasu

Hitoshi Ikeda

Takahiro Ishii

Shigeo Seki

Tetsuro Watanabe

Yujiro Yamada

Eiichi Akita

Tomizo Niwa

Fumio Kai

Yasuharu Sekizawa

Takeo Miyazawa

Osamu Makabe

Shokichi Nakajima

Tatsuo Ito

Zenichiro Ohya

Katsuo Kawakami

Takahiko Kikuchi

Kazunori Oba

Disclosed is an antiviral agent comprising as an active component a substance SF-2140 described in detail in the specification, and a pharmaceutically acceptable carrier. Also disclosed is a method for treatment of viral diseases comprising administering a pharmaceutically effective amount of the substance SF-2140.

Antiviral agents

A new polymeric compound, MF-300, is provided, which possesses a specific protective activity against bacterial infections caused particularly by Pseudomonas aeruginosa. The compound is derived from the reaction of ribostamycin with crotonoyl chloride followed by concentration of the reaction product and by subsequent recovery therefrom of a fraction having a range of molecular weights of 10,000.about.100,000 when measured by ultrafiltration method.

Polymeric compound, MF-300, with protective activity against bacterial

Novel cephalosporin derivatives having formulae (V) and (III): ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.8 and A are defined as in the specification.

Cephalosporin derivatives

A new antiviral agent is now provided, which contains as the active ingredient at least one known glycine derivative of the formula: ##STR1## wherein R is a hydrogen atom, R' is a group --CH.sub.2 NH.sub.2, --CH.sub.2 NHCONH.sub.2, --CH.sub.2 NHCONHOH, --CH.sub.2 CH.sub.2 PO(OH).sub.2, ##STR2## or R and R' taken together form a group ##STR3## and R' is a hydrogen atom or a lower alkyl group, or a pharmaceutically acceptable salt of said glycine derivative. This antiviral agent is useful for therapeutic prevention and treatment of diseases caused by various kinds of viruses.

Antiviral agent and treatment of viral infections

Growing community of inventors

Hachioji, Japan

Yuzo Kazuno