Takeda Chemical Industries, Inc.

Yuzo Ichimori

Hideaki Natsugari

Mitsuhiro Wakimasu

Katsumi Itoh

Koichi Igarashi

Koichi Kondo

Tetsuji Imamoto

Masayuki Ii

Junji Yamada

Tomoyuki Kitazaki

Kyozo Tsukamoto

Masaharu Sendo

Akiyoshi Tani

Cycloalkene derivatives, process for producing the same, and use

The monoclonal antibody generated by immunizing a mammal with human MAP kinase ERK1 and the polyclonal antibody generated by immunizing an animal with the phosphorylation region of the sequence of MAP kinase or a fragment of human MAP kinase are used either alone or in combination to detect and assay various MAP kinase species including ERK2.

Method for assaying ERK2 map kinase

Compounds represented by the formula: ##STR1## wherein the ring A and the ring B each stand for an optionally substituted benzene ring; Ar stands for an optionally substituted aryl group or an optionally substituted heterocyclic group; Q stands for an oxygen atom or a sulfur atom; R stands for a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted hydroxyl group or an optionally substituted amino group; X stands for --O-- or --NR.sup.1 -- wherein R.sup.1 stands for a hydrogen atom or an optionally substituted hydrocarbon group; Y stands for --O--, --NR.sup.2 -- wherein R.sup.2 stands for a hydrogen atom or an optionally substituted hydrocarbon group, or a bond; m denotes 1, 2 or 3, and n denotes 0, 1 or 2, and salts thereof which have excellent calcium- or substance P receptor-antagonistic activity, being useful for treating a cerebralvascular disorder in mammals such as cerebralischemia, cerebral edema and neuronal damage, their production and use.

Isoquinolinyl compounds which are useful in treating cerebral vascular

The present invention provides a hybrid cell line producing monoclonal antibody to an acidic fibroblast growth factor (aFGF) protein. The hybridoma is established by fusing spleen cells from immunized mice with myeloma cells. The hybridomas are cultured as clones, and antibodies obtained from the individual clones are tested for their specificity for aFGF protein. Antibodies can be obtained from the culture growth medium or from ascitic fluid of mice bearing the hybridoma tumor. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.

Monoclonal antibody against an acidic FGF protein and hybridoma for its

The invention relates to novel polypeptide of the formula ##STR1## wherein X is a bond, or a peptide or amino acid residue 1 to 16 amino acids counting from the C terminus of the peptide chain of ##STR2## and Y is a peptide or amino acid residue having 1 to 5 amino acids counting from the N terminus of the peptide chain of ##STR3## and conjugate between the same and a carrier protein, as well as hydridoma and monoclonal antibody derived by the use of the polypeptide or the conjugate, and a method of detecting and of purifying human gamma-interferon using the antibodies.

Novel peptide and use thereof

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Sakai, Japan

Yuzo Ichimori