Igen International, Inc.

Eisai Company, Limited

Bioveris Corporation

Yuzaburo Namba

John H Kenten

Jack E Goodman

Richard J Massey

Gary F Blackburn

Haresh P Shah

George E Lowke

John K Leland

Jonathan K Leland

Toshio Takahashi

Tomiaki Morimoto

Takashi Sawada

Toyohiro Kitamura

Shigenari Kukisaki

Tohru Naraki

Minoru Tohda

An apparatus for performing a binding assay for an analyte of interest present in a sample based upon measurement of electrochemiluminescence at an electrode surface comprising a cell defining a sample containing volume intersecting with inlet and outlet means, an electrode having a substantially horizontally positioned surface exposed to and positioned below a portion of the sample containing volume, means for impressing electrochemical energy upon said electrode sufficient to generate luminescence, means for magnetically collecting particles along said surface and means for measuring the luminescence generated at said electrode.

Methods and apparatus for improved luminescence assays

The invention provides compositions and kits for performing a binding assay for an analyte of interest present in a sample based upon electrochemiluminescence. The compositions and kits comprise an electrochemiluminescent label, collectable particles, binding reagents, and an electrolyte.

Electrochemiluminescent localizable complexes for assay compositions

An apparatus for performing a binding assay for an analyte of interest in a sample based upon measurement of clectrochemiluminescence at an electrode surface comprising: (a) a cell defining a sample; (b) an electrode adjacent a portion of the sample containing volume; (c) a voltage control device for impressing electrochemical energy upon the electrode sufficient to generate luminescence; (d) means for magnetically collecting particles along the electrode surface; and (e) a light detection device for measuring the luminescence.

The invention relates to methods of performing a binding assay for an analyte of interest present in a sample based upon electrochemiluminescence at an electrode of interest. Particles are employed in the method, which are then collected in a zone at which electrochemiluminescence can be induced, wherein the amount of induced electrochemiluminescence is related to the amount of analyte in the sample.

Methods for improved particle electrochemiluminescence assays

The invention relates to methods of performing a binding assay for an analyte of interest present in a sample based upon electrochemiluminescence at an electrode of interest. Particles are employed in the method, which are then collected in a zone at which electrochemiluminescence can be induced, wherein the amount of induced electrochemilurninescence is related to the amount of analyte in the sample.

Methods for improved particle electrochemiluminescence assay

Apparatus for improved luminescence assays

Disclosed and claimed are methods and apparatus for performing a binding assay for an analyte of interest present in a sample based upon measurement of electrochemiluminescence at an electrode. The method uses magnetically responsive particles. The method and apparatus call for a plurality of electromagnets or permanent magnets in north-south orientation for imposing a magnetic field so as to collect the particles.

Method and apparatus for magnetic microparticulate based luminescence

Improved method for the measurement of substance comprising simultaneously measuring a plurality of specimens of a substance to be measured by enzyme immunoassay. The process comprises:

Method for measuring substances by enzyme immunoassay

This washing apparatus comprises holding a pipe assembly by means of a holding means. Said pipe assembly is consisted of a pouring pipe which acts to pour a wash liquid in micro wells of a container and a suction pipe which acts to suck said waste wash liquid from said micro wells. Said pipe assembly is formed of a dual-pipe consisting of a suction pipe and a pouring pipe disposed inside said suction pipe. The forward end opening portions of said both pipes are located on the substantially same plane.

Washing apparatus

An optical continuous measuring apparatus for a reaction-liquid comprises: a microplate provided with a plurality of microcups arranged on a straight line at intervals of a certain distance; a rotary disc provided over the microplate so as to be rotatable, which disc is provided with suction nozzles in its outer periphery, which nozzles are sequentially inserted into the microcups upon rotation of the disc, and also provided with transparent measuring cells communicating therewith inward in radial direction of the disc; suction means for sucking the reaction-liquid received in the microcups from the microcups into the measuring cells through the suction nozzles when the suction nozzles of the rotary disc are inserted into the microcups; an optical measuring means for measuring the reaction-liquid received in the measuring cells; a supplying means for supplying a rinsing liquid to the measuring cells; and a discharging means for discharging the reaction-liquid and the rinsing liquid from the measuring cells.

Growing community of inventors

Ibaraki, Japan

Yuzaburo Namba